Graphostromols A-K, Eleven New Chained Polyketides from the Deep-Sea-Derived Graphostroma sp
Graphostromols A-K, Eleven New Chained Polyketides from the Deep-Sea-Derived Graphostroma sp
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Graphostromols A-K，来自深海衍生的 Graphostroma sp 的 11 种新型链状聚酮化合物
DOI：
10.1002/cbdv.201900326
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发表时间：
2019
影响因子：
2.9
通讯作者：
Yang Xian Wen
中科院分区：
文献类型：
--
作者：
Niu Siwen;Xie Chun Lan;Xia Jin Mei;Zhong Tianhua;Luo Zhuhua;Shao Zongze;Yang Xian Wen
深海真菌Graphostromasp发酵培养物中AcOEt提取物的层析分离。结果分离得到11个新的链状多酮化合物，即粒基质醇A-K(1-11)。通过对其核磁共振和电喷雾质谱数据的广泛分析，确定了新化合物的结构。在改进的Mosher方法的基础上，确定了In1的C-11绝对构型。化合物1-5，具有2，2，10，10-四甲基十二烷骨架，为首次从自然界中发现。所有分离株对五种不同的癌细胞系(HeLa、ECA-109、BIU-87、Bel-7402和PANC-1)的细胞毒性进行了评估。然而，没有一个显示出积极的效果。
Chromatographic separation of the AcOEt extract of the fermented cultures of the deep‐sea‐derived fungusGraphostromasp. resulted in the isolation of 11 new chained polyketides, namely graphostromols A–K (1–11). The structures of the new compounds were established by the extensive analyses of their NMR and HR‐ESI‐MS data. The absolute configuration at C‐11 in1was determined on the basis of the modified Mosher's method. Compounds1–5, bearing a 2,2,10,10‐tetramethyldodecane skeleton, were discovered for the first time from nature. All isolates were evaluated for their cytotoxicities against five different cancer cell lines (HeLa, Eca‐109, Biu‐87, Bel‐7402, and PANC‐1). However, none showed positive effects.