Monoamine oxidase A gene is associated with borderline personality disorder
Monoamine oxidase A gene is associated with borderline personality disorder
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DOI：
10.1097/ypg.0b013e328016831c
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发表时间：
2007-06-01
影响因子：
0.9
通讯作者：
Kennedy, James L.
中科院分区：
文献类型：
--
作者：
Ni, Xingqun;Sicard, Tricia;Kennedy, James L.
目的单胺氧化酶A是一种线粒体酶，参与某些神经递质胺的降解：血清素和去甲肾上腺素。至于它的作用，在侵略，冲动，自杀和情绪的倾向，单胺氧化酶A可以被认为是一个功能的候选人在边缘型人格disorder.Methods为了检验这一假设，我们基因型单胺氧化酶A基因，启动子VNTR和rs6323（T941 G）在外显子8，在111例高加索边缘型人格障碍患者和289名高加索健康对照的两个多态性标记。用UNPHASED中的COCAPHASE程序对单个标记和单倍型数据进行关联分析结果边缘型人格障碍患者中高活性VNTR等位基因频率较高（χ 2 = 4.696，结论单胺氧化酶A基因可能在边缘型人格障碍的发病中起重要作用。
Objective Monoamine oxidase A is a mitochondrial enzyme involved in the degradation of certain neurotransmitter amines: serotonin and norepinephrine. As for its role in aggression, impulsivity, suicide and mood liability, monoamine oxidase A can be considered a functional candidate in borderline personality disorder.Methods To test for this hypothesis we genotyped two polymorphic markers in monoamine oxidase A gene, a promoter VNTR and an rs6323 (T941 G) in exon 8, in 111 Caucasian borderline personality disorder patients and 289 Caucasian healthy controls. Association analyses using individual marker and haplotype data were performed by a program of COCAPHASE in UNPHASED (MRC Human Genome Mapping Project Resource Centre, Cambridge, UK).Results We found that the borderline personality disorder patients had a high frequency of the high activity VNTR alleles (chi(2) = 4.696, P= 0.03) and a low frequency of the low activity haplotype (chi(2) =5.089, P=0.02).Conclusion These results show that the monoamine oxidase A gene may play an important role in the etiological development of the borderline personality disorder.