ANALYSIS OF AGE-RELATED CHOROIDAL LAYERS THINNING IN HEALTHY EYES USING SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY
ANALYSIS OF AGE-RELATED CHOROIDAL LAYERS THINNING IN HEALTHY EYES USING SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY
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DOI：
10.1097/iae.0000000000001347
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发表时间：
2017-07-01
影响因子：
3.3
通讯作者：
Ruiz-Moreno, Jose M.
中科院分区：
文献类型：
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作者：
Ruiz-Medrano, Jorge;Flores-Moreno, Ignacio;Ruiz-Moreno, Jose M.
目的：应用扫描源光学相干断层扫描技术研究健康人群脉络膜层厚度随年龄的变化。方法：回顾分析以往单中心、前瞻性、横断面、非干预性研究中的一组眼的数据。使用扫描源光学相干断层扫描对169只健康眼进行了评估。纳入标准为最佳矫正视力在20/20到20/25之间，屈光度在+/-3之间的等值球镜，以及没有全身或眼部疾病。两名独立的研究人员确定了黄斑水平脉络膜厚度(CT)和以中心凹为中心的9 mm线上的Haller层厚度。结果：中心凹下脉络膜厚度平均为305.76+/-80.59 mm(95%可信区间：294.85-319.33)。Haller层平均黄斑下中心凹厚度为215.47+/-67.7 mm(95%可信区间：207.30~227.86)，脉络膜毛细血管加Sattler层平均黄斑下中心凹厚度为87.31+/-40.40 mm(95%可信区间：83.38~95.65)。性别差异不显著。脉络膜厚度和Haller层厚度随年龄增加而减少的组之间脉络膜厚度分布相似(P=0.002)。结论：不同年龄组脉络膜厚度和Haller层厚度分布相似。年龄相关的脉络膜变薄主要是以损害Haller层为代价的。
Purpose: To study the changes in the choroidal layers thickness with age in a healthy population using swept-source optical coherence tomography.Methods: Retrospective data analysis of a subgroup of eyes from a previous single-center, prospective, cross-sectional, noninterventional study. One hundred and sixty-nine healthy eyes were evaluated using swept-source optical coherence tomography. Inclusion criteria were best-corrected visual acuity between 20/20 and 20/25, spherical equivalent between +/- 3 diopters, and no systemic or ocular diseases. Two independent investigators determined the macular horizontal choroidal thickness (CT) and the Haller's layer thickness across a 9 mm line centered at the fovea. Subjects were divided into five age groups.Results: Mean subfoveal choroidal thickness was 305.76 +/- 80.59 mm (95% confidence interval: 294.85-319.33). Mean subfoveal thickness for Haller's layer was 215.47 +/- 67.70 mm (95% confidence interval: 207.30-227.86) and mean subfoveal thickness for choriocapillaris plus Sattler's layer was 87.31 +/- 40.40 mm (95% confidence interval: 83.38-95.65). No significant differences were found due to gender. Choroidal thickness profile was similar between groups with choroidal thickness and Haller's layer thickness decreasing with age (P = 0.002).Conclusion: Choroidal and Haller's layer thickness profiles are similar between different age groups. Age-related choroidal thinning is mostly at the expense of Haller's layer.