A role for leptin in rheumatic diseases?
A role for leptin in rheumatic diseases?
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DOI：
10.1136/ard.62.10.913
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发表时间：
2003-10-01
影响因子：
27.4
通讯作者：
Gabay, C
中科院分区：
文献类型：
--
作者：
Palmer, G;Gabay, C
Ann Rheum Dis：首次出版为10.1136/ard。62.10. 2003年9月12日第913次。在ob/ob小鼠中，在较晚的时间点从更严重下载。在ob/ob和db/db小鼠中ZIA的延迟消退表明，在该模型中，瘦素显示出抗肿瘤特性。正如先前观察到的全身促炎刺激，18 22瘦素因此也可能参与控制关节局部炎症事件。瘦素在人类风湿性疾病中的作用？据报道，在类风湿性关节炎（RA）患者中，禁食导致疾病活动的不同临床和生物学指标的改善，这与血清瘦素的显著降低和向Th 2细胞因子产生的转变有关。[24]这些特征与ob/ob小鼠AIA期间观察到的特征相似，表明瘦素也可能通过诱导Th 1应答影响人类关节炎的炎症机制。然而，相同的研究人员表明，在RA患者中进行7天生酮饮食后，尽管血清瘦素浓度显著降低，但疾病活动的任何临床或生物学测量均无显著变化。25
Ann Rheum Dis: first published as 10.1136/ard. 62.10. 913 on 12 September 2003. Downloaded from more severe at late time points in ob/ob mice. The delayed resolution of ZIA in ob/ob and db/db mice suggests that, in this model, leptin displays antiinflammatory properties. As previously observed with systemic proinflammatory stimuli, 18 22 leptin may thus also be involved in the control of local inflammatory events in the joint.A ROLE FOR LEPTIN IN HUMAN RHEUMATIC DISEASES? In patients with rheumatoid arthritis (RA) it was reported that fasting leads to an improvement of different clinical and biological measures of disease activity, which was associated with a marked decrease in serum leptin and a shift towards Th2 cytokine production. 24 These features, resembling those seen during AIA in ob/ob mice, suggest that leptin may also influence the inflammatory mechanisms of arthritis in humans through the induction of Th1 responses. However, the same investigators showed that after a seven day ketogenic diet in patients with RA, there were no significant changes in any clinical or biological measurements of disease activity, despite a significant decrease in serum leptin concentrations. 25