E-cadherin repression contributes to c-Myc-induced epithelial cell transformation
E-cadherin repression contributes to c-Myc-induced epithelial cell transformation
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DOI：
10.1038/sj.onc.1210132
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发表时间：
2007-05-01
期刊：
影响因子：
8
通讯作者：
Cole, M. D.
中科院分区：
文献类型：
--
作者：
Cowling, V. H.;Cole, M. D.
c-Myc癌蛋白在相当大比例的人类上皮癌中过表达，并且实验性c-Myc在上皮细胞中的过表达促进肿瘤形成。然而，c-Myc如何促进上皮细胞肿瘤形成尚不清楚。我们报告说，c-Myc在人乳腺上皮细胞的表达诱导细胞形态的显着变化，与一些特征的“上皮间质转化”。在表达c-Myc的细胞中，E-钙粘蛋白的表达受到转录后机制的抑制。此外，E-cadherin抑制是c-Myc诱导的细胞转化所必需的。
c-Myc oncoprotein is overexpressed in a significant proportion of human epithelial cancers, and experimental overexpression of c-Myc in epithelial cells promotes tumour formation. However, it is not known how c-Myc promotes epithelial cell tumour formation. We report that c-Myc expression in human mammary epithelial cells induces a dramatic change in cell morphology, with some characteristics of an 'epithelial to mesenchymal transition'. E-cadherin expression is repressed by a post-transcriptional mechanism in cells expressing c-Myc. Furthermore, E-cadherin repression is necessary for c-Myc-induced cell transformation.