Available data from carminomycin studies in the United States: the acute intermittent intravenous schedule.
Available data from carminomycin studies in the United States: the acute intermittent intravenous schedule.
复制标题
美国洋红霉素研究的可用数据：急性间歇静脉注射方案。
DOI：
10.1007/978-3-642-81565-2_3
复制
发表时间：
1981
期刊：
影响因子：
--
通讯作者：
S. Crooke
中科院分区：
文献类型：
--
作者：
R. Comis;S. Ginsberg;S. Reich;L. Baker;S. Crooke
洋地黄霉素是一种从Carminata Actinomadura菌丝体中分离出来的蒽环类抗肿瘤抗生素[5]。洋红霉素的结构见图1。洋红霉素在立体化学上与柔红霉素非常相似。该分子与柔红霉素的不同之处在于糖苷配基，是去甲基柔红霉素。洋红霉素在多种动物肿瘤系统中具有活性，包括L1210和肉瘤180 [9]。在L1210中，抗肿瘤活性似乎不具有时间表依赖性[2]。洋红霉素经口吸收，小鼠经口与静脉给药的LD_（50）之比为2：1。
Carminomycin is an anthracycline antitumor antibiotic isolated from the mycelia of Actinomadura carminata [5]. The structure of carminomycin is presented in Fig. 1. Carminomycin is steriochemically quite similar to daunorubicin. The molecule differs from daunorubicin in the aglycone, being a desmethyl daunomycin. Carminomycin is active in a variety of animal tumor systems including L1210 and sarcoma 180 [9]. Antitumor activity does not appear to be schedule dependent in L1210 [2]. Carminomycin is orally absorbed, and the ratio of the LD50 of oral to intravenous administration is 2 : 1 in mice.