Association of dental caries and blood lead levels
Association of dental caries and blood lead levels
复制标题
DOI：
10.1001/jama.281.24.2294
复制
发表时间：
1999-06-30
影响因子：
120.7
通讯作者：
Auinger, P
中科院分区：
文献类型：
--
作者：
Moss, ME;Lanphear, BP;Auinger, P
实验表明，接触铅的动物龋齿率较高，目的探讨血铅水平与龋病的关系。1988年至1994年进行了一项包括牙科检查和静脉穿刺血铅测定的横断面调查。参加了第三次全国健康和营养检查调查，该调查评估了美国儿童和成人的健康和营养状况。主要结果测量对于2至11岁的儿童，腐烂和填充的落叶或初级表面的总和;对于6岁及以上的人，腐烂和填充的永久表面的总和;对于那些12岁及以上，腐烂，失踪，和填补surfaces.Results的总和血铅水平的日志显着相关的乳牙和恒牙在所有年龄组的受影响的表面的数量，即使调整后的社会人口特征，饮食，和牙齿护理。在5至17岁的儿童中，血铅水平变化0.24 μ mol/L（5 μ g/dL）与龋齿风险升高相关（比值比，1.8; 95%置信区间，1.3-2.5）。血铅水平的差异解释了美国不同收入水平和地区龋齿患病率的差异。我们估计，人口归因于风险的铅暴露是13.5%和9.6%的龋齿发生在5- 17岁的孩子暴露于高和中等水平，foreign.Conclusions环境铅暴露与龋齿的患病率增加，在美国人口，调查结果可能有助于解释龋齿的收入和地区的美国的分布。
Context Experiments show that dental caries rates are higher among lead-exposed animals, but this association has not been established in humans.Objective To examine the relationship between blood lead levels and dental caries.Design Cross-sectional survey conducted from 1988 to 1994 that included a dental examination and venipuncture blood lead assay.Setting and Participants A total of 24 901 persons aged 2 years and older who participated in the Third National Health and Nutrition Examination Survey, which assessed the health and nutritional status of children and adults in the United States.Main Outcome Measures For children aged 2 to 11 years, the sum of decayed and filled deciduous or primary surfaces; for persons aged 6 years and older, the sum of decayed and filled permanent surfaces; for those 12 years and older, the sum of decayed, missing, and filled surfaces.Results The log of blood lead level was significantly associated with the number of affected surfaces for both deciduous and permanent teeth in all age groups, even after adjusting for sociodemographic characteristics, diet, and dental care. Among children aged 5 to 17 years, a 0.24-mu mol/L (5-mu g/dL) change in blood lead level was associated with an elevated risk of dental caries (odds ratio, 1.8; 95% confidence interval, 1.3-2.5). Differences in blood lead level explained some of the differences in caries prevalence in different income levels and regions of the United States. We estimated the population attributable risk of lead exposure to be 13.5% and 9.6% of dental caries occurring in 5- to 17-year-olds exposed to the high and moderate levels, respectively.Conclusions Environmental lead exposure is associated with an increased prevalence of dental caries in the US population, Findings may help explain the distribution of caries by income and region of the United States.