C-type natriuretic peptides stimulate chloride secretion in the rectal gland of Squalus acanthias.
C-type natriuretic peptides stimulate chloride secretion in the rectal gland of Squalus acanthias.
复制标题
C 型钠尿肽刺激棘角鲨直肠腺中的氯离子分泌。
DOI：
10.1152/ajpregu.1992.262.4.r707
复制
发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Silva,P
中科院分区：
文献类型：
--
作者：
Solomon,R;Protter,A;McEnroe,G;Porter,JG;Silva,P
将同源鲨鱼C型利尿钠肽（sCNP）以推注和持续输注的方式输注到同一物种棘角鲨的离体灌注直肠腺中。sCNP是一种有效的氯化物分泌刺激剂，其剂量-反应曲线与血管活性肠肽相似。sCNP与Killifish CNP等效，但比人CNP（hCNP）更有效。截短和取代形式的hCNP也能够刺激氯化物分泌，顺序为hCNP大于hCNP（6-22）= [Gly 9]hCNP大于hCNP-（7-21）。sCNP比人心钠素（hANP）更有效，而hANP比猪脑钠素更有效。hANP-（31-67）无明显作用。这些研究表明，sCNP可能是直肠腺功能的生理调节剂。直肠腺中的受体尚不清楚，但根据效力顺序，NH 2末端的位置4和环本身对配体效应很重要。
Homologous shark C-type natriuretic peptide (sCNP) was infused as a bolus and as a constant infusion in the isolated perfused rectal gland of the same species, Squalus acanthias. sCNP was a potent stimulator of chloride secretion similar in its dose-response curve to vasoactive intestinal peptide. sCNP was equipotent with killifish CNP but more potent than human CNP (hCNP). Truncated and substituted, forms of hCNP were also capable of stimulation of chloride secretion in the order hCNP greater than hCNP (6-22) = [Gly9]hCNP greater than hCNP-(7-21). sCNP was more potent than human atrial natriuretic peptide (hANP), which was more potent than porcine brain natriuretic peptide. hANP-(31-67) was without effect. These studies suggest that sCNP may be the physiological regulator of rectal gland function. The receptor in the rectal gland is unknown but based on the order of potencies, position 4 in the NH2-terminal end and the ring itself are important for ligand effects.