Treatment of vitiligo by transplantation of cultured pure melanocyte suspension: Analysis of 120 cases
Treatment of vitiligo by transplantation of cultured pure melanocyte suspension: Analysis of 120 cases
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DOI：
10.1016/j.jaad.2003.12.013
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发表时间：
2004-07-01
影响因子：
13.8
通讯作者：
Hung, CM
中科院分区：
文献类型：
--
作者：
Chen, YF;Yang, PY;Hung, CM
背景：尽管白癜风的各种药物治疗的可用性，很大比例的患者未能达到令人满意的结果。目的：评价自体纯黑素细胞培养治疗白癜风的可行性，并探讨其在稳定期局限型白癜风、稳定期泛发型白癜风和活动期泛发型白癜风中的差异。方法：对120例白癜风患者进行了二氧化碳激光治疗后自体培养纯黑素细胞悬液移植治疗。稳定型局限性白癜风患者的色素沉着恢复率最高，84%达到90%至100%的覆盖率，其次是54%的稳定型泛发性白癜风患者，而只有14%的活动性泛发性白癜风患者经历了良好的色素恢复。年龄和性别的患者，和大小和位置的病变，并没有表现出显着的影响结果的transplantation.Conclusion：自体培养的纯黑素细胞悬液结合二氧化碳激光擦伤是一种有效的治疗稳定型白癜风患者谁不响应的药物治疗，特别是那些稳定的局限性白癜风。
Background: Despite the availability of various medical treatments for vitiligo, a large percentage of patients fail to achieve satisfactory results. Surgical techniques offer a potential solution for patients with vitiligo who fail to respond to medical treatments.Objective: We evaluated the practicality in treating vitiligo by using cultured autologous pure melanocytes and investigated the different results among stable localized vitiligo, stable generalized vitiligo, and active generalized vitiligo.Methods: In all, 120 patients with vitiligo were treated with transplantation Of autologous Cultured pure melanocyte suspension after carbon-dioxide laser abrasion.Results: Patient, with stable localized vitiligo experienced the highest percentage of excellent repigmentation with 84% achieving 90% to 100% coverage, followed by 54% of patients with stable generalized vitiligo, whereas only 14% of patients with active generalized vitiligo experienced good repigmentation. Age and sex of the patients, and size and location of the lesions, did not show significant influence on the results of transplantation.Conclusion: Autologous cultured pure melanocyte suspension combined with carbon-dioxide laser abrasion is an effective treatment for patients with stable vitiligo who fail to respond to medical treatments, especially for those with stable localized vitiligo.