Estrogen withdrawal selectively increases serotonin reactivity in rabbit basilar artery.
Estrogen withdrawal selectively increases serotonin reactivity in rabbit basilar artery.
复制标题
雌激素撤退选择性地增加兔基底动脉的血清素反应性。
DOI：
10.1016/0024-3205(94)00642-3
复制
发表时间：
1994
期刊：
影响因子：
6.1
通讯作者：
Moss,J
中科院分区：
文献类型：
--
作者：
Shay,J;Futo,J;Badrov,N;Moss,J
临床观察和实验室调查表明，性别和月经状态调节脑血管反应性。我们准备了7组兔(I)雄兔(II)去卵巢未处理的雌兔，(III)去卵巢的雌兔，(IV)超排的雌兔，(V)超排的雌兔，(VI)去卵巢的雌兔，(Vii)去势的雌兔，并在体外比较脑基底动脉对5-羟色胺(5-HT)和去甲肾上腺素(NE)的反应性。与保持雌激素和其他组相比，卵巢切除、急性雌激素撤除的女性(第七组)的基底动脉对5-羟色胺血管收缩的敏感性增加(P<；0.0001)。超排女性的5-羟色胺敏感性显著降低(P<；0.001)。5-羟色胺敏感性的改变是选择性的，NE没有观察到。无论激素水平如何，硝基精氨酸处理和机械剥离均导致NE和5-羟色胺的Tmax升高，ED50降低。我们得出结论，雌激素停用通过内皮非依赖性机制增加5-羟色胺的血管反应性。
Clinical observations and laboratory investigations suggest that gender and menstrual status modulate cerebrovascular reactivity. We prepared 7 groups of rabbits (I) males (II) oophorectomized untreated females, (III) testosterone treated oophorectomized females, (IV) superovulated females, (V) superovulated estrogen withdrawn females, (VI) estrogen treated oophorectomized females, and (VII) estrogen withdrawn females to mimic phases of the estrous cycle and compare cerebral basilar artery reactivity to serotonin (5-HT) and norepinephrine (NE) in vitro. Basilar artery sensitivity to 5-HT vasoconstriction was increased in oophorectomized, acutely estrogen withdrawn females (Group VII) when compared to estrogen maintained and the other groups (p<0.0001). There was a significant reduction in 5-HT sensitivity in superovulated females (Group IV) (p<0.001). The change in 5-HT sensitivity is selective and was not observed for NE. Nitroargenine treatment and mechanical denudement resulted in higher Tmaxand lower ED50for both NE and 5-HT regardless of hormonal manipulation. We conclude that estrogen withdrawal increases 5-HT vasoreactivity by an endothelium independent mechanism.