REFINED SECONDARY STRUCTURE MODELS FOR THE 16S AND 23S RIBOSOMAL-RNA OF ESCHERICHIA-COLI
REFINED SECONDARY STRUCTURE MODELS FOR THE 16S AND 23S RIBOSOMAL-RNA OF ESCHERICHIA-COLI
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DOI：
10.1093/nar/11.21.7263
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发表时间：
1983-01-01
影响因子：
14.9
通讯作者：
BRIMACOMBE, R
中科院分区：
文献类型：
--
作者：
MALY, P;BRIMACOMBE, R
已发表的核糖体RNA（或rDNA）的全部序列，总计超过50，000个碱基，已被用于推导来自E.杆菌特别注意解决这些分子的各种已发表的二级结构之间的差异。其结构由133个螺旋区（16S RNA为45个，23S RNA为88个）描述。其中约有20项仍是暂定或未经确认的。另外20个代表明确存在的螺旋区域，但其中详细的碱基配对仍有待讨论。然而，超过90个螺旋区域现在精确地建立，至少在一个或两个碱基对内。
The complete range of published sequences for riboaomal RNA (or rDNA), totalling well over 50,000 bases, has been used to derive refined models for the secondary structures of both 16S and 23S RNA from E. coli. Particular attention has been paid to resolving the differences between the various published secondary structures for these molecules. The structures are described in terms of 133 helical regions (45 for 16S RNA and 88 for 23S RNA). Of these, approximately 20 are still tentative or unconfirmed. A further 20 represent helical regions which definitely exist, but where the detailed base-pairing is still open to discussion. Over 90 of the helical regions are however now precisely established, at least to within one or two base pairs.