Palladium-catalyzed coupling of ammonia and lithium amide with aryl halides
Palladium-catalyzed coupling of ammonia and lithium amide with aryl halides
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DOI：
10.1021/ja064005t
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发表时间：
2006-08-09
影响因子：
15
通讯作者：
Hartwig, John F.
中科院分区：
文献类型：
--
作者：
Shen, Qilong;Hartwig, John F.
本文描述了一种温和的、钯催化的芳基卤与氨或氨基锂的偶联反应，以形成作为主要产物的伯芳胺。这些反应以形成伯芳基胺相对于形成二芳基胺的优异选择性发生（芳基胺与二芳基胺的比率为9.5：1至超过50：1）。此外，第一个与末端− NH2配体的有机钯配合物已经被分离出来。该络合物还原消除以形成芳胺。
A mild, palladium-catalyzed coupling of aryl halides with ammonia or lithium amide to form primary arylamines as the major product is described. These reactions occurred with excellent selectivity for formation of the primary arylamine over formation of the diarylamine (9.5:1 to over 50:1 ratios of arylamine to diarylamine). In addition, the first organopalladium complex with a terminal −NH2ligand has been isolated. This complex reductively eliminates to form arylamines.