Combination of 5-flucytosine and capsule-binding monoclonal antibody in the treatment of murine Cryptococcus neoformans infections and in vitro
Combination of 5-flucytosine and capsule-binding monoclonal antibody in the treatment of murine Cryptococcus neoformans infections and in vitro
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DOI：
10.1093/jac/37.3.617
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发表时间：
1996-03-01
影响因子：
5.2
通讯作者：
Casadevall, A
中科院分区：
文献类型：
--
作者：
Feldmesser, M;Mukherjee, J;Casadevall, A
采用J774.16小鼠巨噬细胞样细胞体外试验和小鼠隐球菌感染体内试验，研究了5-氟胞嘧啶和抗新生隐球菌荚膜葡萄糖醛酸甘露聚糖单克隆抗体IgG 1联合治疗的疗效。5-氟胞嘧啶和IgG 1联合应用能更有效地减少C.在体外和体内，比单独的任一种药剂更能促进新生儿的集落形成单位。
The efficacy of combination therapy with 5-flucytosine and an IgG1 monoclonal antibody to Cryptococcus neoformans capsular glucuronoxylomannan was studied in vitro with J774.16 murine macrophage-like cells and in vivo in murine cryptococcal infection. The combination of 5-flucytosine and IgG1 was more effective in reducing the numbers of C. neoformans colony-forming units in vitro and in vivo than either agent alone.