Information transfer between duplicated chromosomal sequences in mammalian cells involves contiguous regions of DNA.
Information transfer between duplicated chromosomal sequences in mammalian cells involves contiguous regions of DNA.
复制标题
哺乳动物细胞中复制的染色体序列之间的信息传递涉及 DNA 的连续区域。
DOI：
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发表时间：
1986
影响因子：
11.1
通讯作者：
J. Stachelek
中科院分区：
文献类型：
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作者：
R. Liskay;J. Stachelek
我们已经调查的信息传递的性质，似乎发生在培养的小鼠L细胞中的重复的染色体序列之间的非重复性。我们研究了两种不同的缺陷型胸苷激酶基因之间的基因转换，来自两个密切相关的株1型单纯疱疹病毒，并共享一个沉默的限制性位点多态性。我们的研究结果表明，这个沉默的网站可以共转换沿着与选定的突变位点。这些发现与基因转换的机制是一致的，该机制涉及长度、位置或两者都不同的连续DNA块。一个额外的发现是，涉及沉默网站的共转化事件的产品是不平等的恢复，虽然在四个不同的选择网站观察到的转换率是相似的。
We have investigated the nature of information transfer that appears to occur nonreciprocally between duplicated chromosomal sequences in cultured mouse L cells. We have studied gene conversion between two different defective thymidine kinase genes derived from two closely related strains of type 1 herpes simplex virus and that share a silent restriction site polymorphism. Our results demonstrate that this silent site can be coconverted along with the selected mutant sites. The findings are consistent with a mechanism of gene conversion that involves contiguous blocks of DNA differing in length, position, or both. An additional finding is that the products of coconversion events involving the silent site are unequally recovered although the rates of conversion observed at four different selected sites are similar.
小鼠细胞中重复染色体序列之间的同源重组。
DOI：
10.1101/sqb.1984.049.01.021
发表时间：
1984
期刊：
Cold Spring Harbor symposia on quantitative biology
影响因子：
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作者：
Liskay,RM;Stachelek,JL;Letsou,A
通讯作者：
Letsou,A