INHIBITION OF NEUTROPHIL LYSOSOME-PHAGOSOME FUSION ASSOCIATED WITH INFLUENZA-VIRUS INFECTION INVITRO - ROLE IN DEPRESSED BACTERICIDAL ACTIVITY
INHIBITION OF NEUTROPHIL LYSOSOME-PHAGOSOME FUSION ASSOCIATED WITH INFLUENZA-VIRUS INFECTION INVITRO - ROLE IN DEPRESSED BACTERICIDAL ACTIVITY
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DOI：
10.1172/jci110580
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发表时间：
1982-01-01
影响因子：
15.9
通讯作者：
BASS, DA
中科院分区：
文献类型：
--
作者：
ABRAMSON, JS;LEWIS, JC;BASS, DA
本文研究了不同甲型流感病毒株对人多形核白细胞（PMNL）髓过氧化物酶（MPO）和酸性磷酸酶（AP）释放的影响。这些结果与这些相同病毒对PMNL中杀菌活性的影响相关。几种病毒株抑制嗜天青颗粒与含有金黄色葡萄球菌的吞噬体的融合。这些相同的菌株抑制PMNL的MPO的细胞外释放（39-59%）并引起抑制性杀伤（42-77%）。其中一种流感病毒（X-47 a）并不抑制PMNL MPO的释放或杀伤。因此，流感病毒消融正常细胞内溶酶体-吞噬体融合的能力与随后抑制PMNL的杀菌功能之间存在密切关系。
The effect of various unopsonized strains of influenza A virus on release of myeloperoxidase (MPO) and acid phosphatase in human polymorphonuclear leukocytes (PMNL) was studied. These results were correlated with the effect that these same viruses had on bactericidal activity in PMNL. Several strains of virus inhibited the fusion of azurophil granules with phagosomes containing Staphylococcus aureus. These same strains inhibited the extracellular release of MPO from PMNL (39-59%) and caused depressed killing (42-77%). One of the influenza viruses (X-47a) did not inhibit PMNL MPO release or killing. Thus, a close relationship between the ability of influenza virus to ablate normal intracellular lysosome-phagosome fusion with subsequent depression of bactericidal functions of PMNL is indicated.