Age-specific hospitalization risk of primary and secondary respiratory syncytial virus infection among young children
Age-specific hospitalization risk of primary and secondary respiratory syncytial virus infection among young children
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DOI：
10.1016/j.ijid.2022.09.008
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发表时间：
2022-09-26
影响因子：
8.4
通讯作者：
Nishiura, Hiroshi
中科院分区：
文献类型：
--
作者：
Nakajo, Ko;Nishiura, Hiroshi
目的：阐明导致幼儿严重呼吸道合胞病毒（RSV）肺炎和住院治疗的感染动力学至关重要。我们探讨了感染奇偶性以及年龄在几个月的RSV相关的住院幼儿在Japan.Methods的作用：我们使用了一个连续的传输催化模型，以捕捉RSV的传播机制在流行状态的婴儿。我们调查了日本年龄相关的血清阳性率和住院发生率的数据，并联合估计了在原发性RSV感染期间住院的年龄特异性风险和在继发性感染期间住院的相对风险，
Objectives: Elucidating the infection dynamics that lead to severe respiratory syncytial virus (RSV) pneumonia and hospitalization among young children are critical. We explored the role of infection parity as well as age in months for RSV-associated hospitalization among young children in Japan.Methods: We used a sequential transmission catalytic model to capture the transmission mechanisms of RSV among infants in an endemic state. We investigated data on the age-dependent seroprevalence and incidence rate of hospitalization in Japan, and jointly estimated the age-specific risk of hospitalization during primary RSV infection and relative risk of hospitalization during secondary infection in children aged