DTI and MTR abnormalities in schizophrenia: Analysis of white matter integrity
DTI and MTR abnormalities in schizophrenia: Analysis of white matter integrity
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DOI：
10.1016/j.neuroimage.2005.03.026
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发表时间：
2005-07-15
期刊：
影响因子：
5.7
通讯作者：
Shenton, ME
中科院分区：
文献类型：
--
作者：
Kubicki, M;Park, H;Shenton, ME
精神分裂症的弥散张量成像（DTI）研究表明，白质内各向异性弥散降低，这要么是由于白质纤维束的连贯性丧失，要么是由于相互连接的纤维束的数量和/或密度改变，要么是由于髓鞘形成改变，尽管不同研究之间此类改变的方法以及定位有所不同。本研究的目的是通过将DTI与磁化传递成像（MTI）相结合来定位并进一步明确精神分裂症中的DTI异常，MTI是一种对髓鞘和轴突改变敏感的技术，以提高DTI发现的特异性。对21名慢性精神分裂症患者和26名对照者使用线扫描弥散成像和有/无饱和脉冲（MT）的T1加权技术进行扫描。利用多通道守护进程算法（专门设计用于处理多方向张量信息），将弥散信息用于将分数各向异性（FA）和磁化传递率（MTR）的共同配准图归一化到特定研究的模板。精神分裂症患者在以下脑区弥散各向异性降低：穹窿、胼胝体、双侧扣带束、双侧枕额上束、双侧内囊、右侧枕额下束和左侧弓状束。MTR图显示胼胝体、穹窿、右侧内囊和双侧枕额上束有改变；然而，在前扣带束、左侧内囊、弓状束或枕额下束未发现改变。此外，精神分裂症患者右侧后扣带束显示MTR改变但FA无改变。这些发现表明，虽然精神分裂症中的一些弥散异常可能是由于纤维束的连贯性或组织异常，但其中一些异常实际上可能归因于髓鞘/轴突破坏或与之同时发生。（c）2005爱思唯尔公司。保留所有权利。
Diffusion tensor imaging (DTI) studies in schizophrenia demonstrate lower anisotropic diffusion within white matter due either to loss of coherence of white matter fiber tracts, to changes in the number and/or density of interconnecting fiber tracts, or to changes in myelination, although methodology as well as localization of such changes differ between studies. The aim of this study is to localize and to specify further DTI abnormalities in schizophrenia by combining DTI with magnetization transfer imaging (MTI), a technique sensitive to myelin and axonal alterations in order to increase specificity of DTI findings. 21 chronic schizophrenics and 26 controls were scanned using Line-Scan-Diffusion-Imaging and T1-weighted techniques with and without a saturation pulse (MT). Diffusion information was used to normalize co-registered maps of fractional anisotropy (FA) and magnetization transfer ratio (MTR) to a study-specific template, using the multi-channel daemon algorithm, designed specifically to deal with multidirectional tensor information. Diffusion anisotropy was decreased in schizophrenia in the following brain regions: the fornix, the corpus callosum, bilaterally in the cingulum bundle, bilaterally in the superior occipito-frontal fasciculus, bilaterally in the internal capsule, in the right inferior occipito-frontal fasciculus and the left arcuate fasciculus. MTR maps demonstrated changes in the corpus callosum, fornix, right internal capsule, and the superior occipito-frontal fasciculus bilaterally; however, no changes were noted in the anterior cingulum bundle, the left internal capsule, the arcuate fasciculus, or inferior occipitofrontal fasciculus. In addition, the right posterior cingulum bundle showed MTR but not FA changes in schizophrenia. These findings suggest that, while some of the diffusion abnormalities in schizophrenia are likely due to abnormal coherence, or organization of the fiber tracts, some of these abnormalities may, in fact, be attributed to or coincide with myelin/axonal disruption. (c) 2005 Elsevier Inc. All rights reserved.