Yeast dom34 mutants are defective in multiple developmental pathways and exhibit decreased levels of polyribosomes.
Yeast dom34 mutants are defective in multiple developmental pathways and exhibit decreased levels of polyribosomes.
复制标题
酵母 dom34 突变体在多种发育途径中存在缺陷，并且表现出多核糖体水平降低。
DOI：
10.1093/genetics/149.1.45
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发表时间：
1998
期刊：
影响因子：
3.3
通讯作者：
Engebrecht,J
中科院分区：
文献类型：
--
作者：
Davis,L;Engebrecht,J
The DOM34 gene of Saccharomyces cerevisiae is similar togenes found in diverse eukaryotes and archaebacteria. Analysis of dom34 strains shows that progression through the G1phase of the cell cycle is delayed, mutant cells enter meiosis aberrantly, and their ability to form pseudohyphae is significantly diminished. RPS30A, which encodes ribosomal protein S30, was identified in a screen for high-copy suppressors of the dom34Δ growth defect. dom34Δ mutants display an altered polyribosome profile that is rescued by expression of RPS30A. Taken together, these data indicate that Dom34p functions in protein translation to promote G1progression and differentiation. A Drosophila homolog of Dom34p, pelota, is required for the proper coordination of meiosis and spermatogenesis. Heterologous expression of pelota in dom34Δ mutants restores wild-type growth and differentiation, suggesting conservation of function between the eukaryotic members of the gene family.
