Antioxidant activities for superoxide dismutase in patients with Crohn's disease
Antioxidant activities for superoxide dismutase in patients with Crohn's disease
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DOI：
10.1515/jbcpp-2013-0042
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发表时间：
2014-02-01
影响因子：
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通讯作者：
Al-Jebreen, Abdulrahman M.
中科院分区：
文献类型：
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作者：
Alzoghaibi, Mohammed A.;Al-Mofleh, Ibrahem A.;Al-Jebreen, Abdulrahman M.
背景资料：在这项研究中，我们的目的是确定超氧化物歧化酶（SOD）酶的抗氧化活性的水平与克罗恩病（CD）患者的组织损伤的CD。方法：42例CD患者和38名匹配的健康受试者（对照组）被招募。结果：CD患者血浆SOD抗氧化活性明显低于对照组，CD患者血浆SOD抗氧化活性降低是CD患者氧化应激的重要指标。CD患者更容易受到氧化应激的影响。这项研究支持了CD中氧化应激增加和抗氧化防御降低的假设。
Background: In this study, we aimed to determine the levels of antioxidant activity for superoxide dismutase (SOD) enzymes in patients with Crohn's disease (CD) to investigate their contribution to tissue injury in CD.Methods: Forty-two patients with CD and 38 matched healthy subjects (control group) were recruited. SOD enzymatic activity was measured by purely chemical system based on NAD(P)H oxidation.Results: Plasma antioxidant activities for SOD in CD patients were significantly lower than that in the control group.Conclusions: Low antioxidant activity for SOD in CD is an important indication of oxidative stress. CD patients are more susceptible to oxidative stress. This study supports the hypothesis that increased oxidative stress and decreased antioxidant defense in CD.