Extreme obesity and risk of stillbirth among black and white gravidas
Extreme obesity and risk of stillbirth among black and white gravidas
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DOI：
10.1097/01.aog.0000270159.80607.10
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发表时间：
2007-09-01
影响因子：
7.2
通讯作者：
Alexander, Greg R.
中科院分区：
文献类型：
--
作者：
Salihu, Hamisu M.;Dunlop, Anne-Lang;Alexander, Greg R.
OBJECTIVE: To estimate the risk for stillbirth among three generally accepted obesity subtypes based on severity.METHODS: We used the Missouri maternally linked cohort data containing births from 1978 to 1997. Using prepregnancy weight and height, mothers were classified on the basis of calculated body mass index (BMI) above 30 into three subsets: class 1 (30-34.9), class 11 (35-39.9), and extreme obesity (greater than or equal to 40). Using normal-weight, white women (18.5-24.9) as a reference, we applied Cox proportional hazard regression models to estimate risks for stillbirth.RESULTS: The prevalence of obesity in pregnant women was 9.5% (12.8% among blacks and 8.9% among whites). Overall, obese mothers were about 40% more likely to experience stillbirth compared with nonobese gravidas (adjusted hazard ratio 1.4; 95% confidence interval [CI] 1.31.5). The risk for stillbirth increased in a dose-dependent fashion with increase in BMI: class I (adjusted hazard ratio 1.3; 95% CI 1.2-1.4); class 11 (adjusted hazard ratio 1.4; 95% CI 1.3-1.6) and extreme obesity (adjusted hazard ratio 1.9; 95% CI 1.6-2.1; P for trend
