Sporadic inclusion body myositis: Pilot study on the effects of a home exercise program on muscle function, histopathology and inflammatory reaction
Sporadic inclusion body myositis: Pilot study on the effects of a home exercise program on muscle function, histopathology and inflammatory reaction
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DOI：
10.1080/16501970306110
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发表时间：
2003-01-01
影响因子：
3.5
通讯作者：
Borg, K
中科院分区：
文献类型：
--
作者：
Arnardottir, S;Alexanderson, H;Borg, K
目的：评估的安全性和影响的家庭训练计划的肌肉功能在7例散发性包涵体myosis.Design：患者进行锻炼，每周5天，超过12周的periods.Methods：安全性进行了评估，临床检查，反复肌肉活检和血清肌酸激酶水平。肌肉力量的临床检查，动态测力计和功能指数在myosis.Results：强度没有显着提高后，运动，但没有患者恶化有关肌肉功能。组织病理学无变化，肌肉活检中没有肌肉炎症增加或细胞因子和粘附分子表达的迹象。肌酸激酶水平无变化。一个显着的减少被发现在该地区的EN-4（内皮细胞的标记物）在肌肉活检阳性染色后training.Conclusion：家庭锻炼计划被认为是无害的肌肉肌肉炎症和功能。运动可以防止由于疾病和/或不活动而导致的肌肉力量损失。
Objective: To evaluate the safety and effect of a home training program on muscle function in 7 patients with sporadic inclusion body myositis.Design: The patients performed exercise 5 days a week over a 12-week period.Methods: Safety was assessed by clinical examination, repeated muscle biopsies and serum levels of creatine kinase. Muscle strength was evaluated by clinical examination, dynamic dynamometer and by a functional index in myositis.Results: Strength was not significantly improved after the exercise, however none of the patients deteriorated concerning muscle function. The histopathology was unchanged and there were no signs of increased muscle inflammation or of expression of cytokines and adhesion molecules in the muscle biopsies. Creatine kinase levels were unchanged. A significant decrease was found in the areas that were positively stained for EN-4 (a marker for endothelial cells) in the muscle biopsies after training.Conclusion: The home exercise program was considered as not harmful to the muscles regarding muscle inflammation and function. Exercise may prevent loss of muscle strength due to disease and/or inactivity.