Heightened expression of cyclooxygenase-2 and peroxisome proliferator-activated receptor-delta in human endometrial adenocarcinoma.
Heightened expression of cyclooxygenase-2 and peroxisome proliferator-activated receptor-delta in human endometrial adenocarcinoma.
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人类子宫内膜腺癌中环氧合酶 2 和过氧化物酶体增殖物激活受体 δ 的表达升高。
DOI：
10.1038/sj.neo.7900119
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Dey,SK
中科院分区：
文献类型：
--
作者：
Tong,BJ;Tan,J;Tajeda,L;Das,SK;Chapman,JA;DuBois,RN;Dey,SK
流行病学研究表明，非甾体抗炎药（NSAID）可显著降低结直肠癌的风险和死亡率，部分原因是抑制前列腺素（PG）的合成。环氧合酶（考克斯）是PG生物合成的限速酶，存在两种异构体，考克斯-1和考克斯-2。遗传学和药理学证据表明，考克斯-2参与结直肠癌的发生。我们以前的研究表明，考克斯-2衍生的前列环素通过激活过氧化物酶体增殖物激活受体δ（过氧化物酶体增殖物激活受体δ）参与胚泡着床，过氧化物酶体增殖物激活受体δ是核激素受体家族的一员。此外，我们最近的研究表明，类似的途径是在大肠癌的发生。这些观察结果促使我们研究考克斯-2-PPAR 6信号通路是否也参与子宫腺癌的发展。在此，我们首次报道了子宫内膜腺癌中考克斯-2和过氧化物酶体增殖物激活受体δ的高表达，而考克斯-1没有表达。
Epidemiological studies indicate that nonsteroidal anti-inflammatory drugs (NSAIDs) significantly reduce the risk and mortality from colorectal cancer, in part by inhibiting prostaglandin (PG) synthesis. Cyclooxygenase (COX), the rate-limiting enzyme in PG biosynthesis, exists in two isoforms, COX-1 and COX-2. Genetic and pharmacological evidences suggest that COX-2 is involved in the development of colorectal cancer. We have previously shown that COX-2derived prostacyclin participates in blastocyst implantation through activation of peroxisome proliferator activated receptor δ (PPARδ), a member of the nuclear hormone receptor family. Furthermore, our recent studies suggest that a similar pathway is operative during colorectal carcinogenesis. These observations prompted us to examine whether the COX-2-PPAR6 signaling pathway is also involved during development of uterine adenocarcinoma. Here we describe for the first time the heightened expression of COX-2 and PPARδ, but not COX-1, in uterine endometrial adenocarcinoma.