Neuroprotective effects of spermine following hypoxia-ischemia-induced brain damage: A mechanistic study
Neuroprotective effects of spermine following hypoxia-ischemia-induced brain damage: A mechanistic study
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DOI：
10.1096/fj.03-1203fje
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发表时间：
2004-05-01
期刊：
影响因子：
4.8
通讯作者：
Appleton, I
中科院分区：
文献类型：
--
作者：
Clarkson, AN;Liu, HZ;Appleton, I
在神经变性模型中，多胺(精胺、腐胺和亚精胺)可以具有神经毒性或神经保护特性。然而，在缺氧缺血(HI)模型中的评估还没有定义。此外，神经保护的可能机制还没有被阐明。因此，本研究检测了多胺对HI幼鼠模型的影响，并确定了其对参与炎症的关键酶，即一氧化氮合酶(NOS)和精氨酸酶的影响。此外，还研究了对线粒体功能的影响。多胺或生理盐水均予腹腔注射。HI10 mg/kg/d，连续6天。HI后7d组织学检查仅精胺组差异有统计学意义(P
The polyamines (spermine, putrescine, and spermidine) can have neurotoxic or neuroprotective properties in models of neurodegeneration. However, assessment in a model of hypoxia ischemia (HI) has not been defined. Furthermore, the putative mechanisms of neuroprotection have not been elucidated. Therefore, the present study examined the effects of the polyamines in a rat pup model of HI and determined effects on key enzymes involved in inflammation, namely, nitric oxide synthase (NOS) and arginase. In addition, effects on mitochondrial function were investigated. The polyamines or saline were administered i.p. at 10mg/kg/day for 6 days post-HI. Histological assessment 7 days post-HI revealed that only spermine significantly ( P