Reaction time to peripheral visual stimuli during exercise under hypoxia
Reaction time to peripheral visual stimuli during exercise under hypoxia
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DOI：
10.1152/japplphysiol.01115.2009
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发表时间：
2010-05-01
影响因子：
3.3
通讯作者：
Kokubu, Masahiro
中科院分区：
文献类型：
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作者：
Ando, Soichi;Yamada, Yosuke;Kokubu, Masahiro
作者：Ando S，Yamada Y，Kokubu M.低氧条件下运动时对周边视觉刺激的反应时。J Appl Physiol 108：1210-1216，2010.首次发表于2010年2月18日; doi：10.1152/japplphysiol.01115.2009。本研究的目的是检验以下假设：大脑氧合的降低会损害个体在运动期间对外周视觉刺激做出反应的能力。我们在三种不同的工作负荷[40%、60%和80%峰值摄氧量（（V）/dotO（2））]下，在常氧[吸入氧分数（FI（O2））= 0.21]或常压缺氧（FI（O2））= 0.16）下，测量了静息时、骑行期间和骑行后对周边视觉刺激的简单反应时间（RT）。周边视觉刺激呈现在眼睛中点的右侧或左侧10度处。在RT测量期间，用近红外光谱法监测右额叶皮层的脑氧合。我们使用RT（运动前时间）的运动前成分来评估运动对中枢过程的影响。运动前时间在80%峰（V）超过dotO（2）时（常氧：214.2 +/- 33.0 ms，缺氧：221.5 +/- 30.1 ms）显著长于静息时（常氧：201.0 +/- 27.2 ms，缺氧：202.9 +/- 29.7 ms）（P < 0.01）。在常氧条件下，脑氧合逐渐增加，最高达dotO（2）的60%峰值（V），然后下降至dotO（2）的80%峰值（V）的静息水平。在低氧条件下，随着运动负荷的增加，脑氧合进行性降低。我们发现运动前时间的增加与脑氧合的减少之间有很强的相关性（r（2）= 0.89，P < 0.01），表明运动时运动前时间的增加与脑氧合的减少有关。因此，在高海拔锻炼可能损害视觉感知性能。
Ando S, Yamada Y, Kokubu M. Reaction time to peripheral visual stimuli during exercise under hypoxia. J Appl Physiol 108: 1210-1216, 2010. First published February 18, 2010; doi:10.1152/japplphysiol.01115.2009.-The purpose of this study was to test the hypothesis that decrease in cerebral oxygenation compromises an individual's ability to respond to peripheral visual stimuli during exercise. We measured the simple reaction time (RT) to peripheral visual stimuli at rest and during and after cycling at three different workloads [40%, 60%, and 80% peak oxygen uptake ((V) over dotO(2))] under either normoxia [inspired fraction of oxygen (FI(O2)) = 0.21] or normobaric hypoxia (FI(O2)) = 0.16). Peripheral visual stimuli were presented at 10 degrees to either the right or the left of the midpoint of the eyes. Cerebral oxygenation was monitored during the RT measurement over the right frontal cortex with near-infrared spectroscopy. We used the premotor component of RT (premotor time) to assess effects of exercise on the central process. The premotor time was significantly longer during exercise at 80% peak (V)over dotO(2) (normoxia: 214.2 +/- 33.0 ms, hypoxia: 221.5 +/- 30.1 ms) relative to that at rest (normoxia: 201.0 +/- 27.2 ms, hypoxia: 202.9 +/- 29.7 ms) (P < 0.01). Under normoxia, cerebral oxygenation gradually increased up to 60% peak (V) over dotO(2) and then decreased to the resting level at 80% peak (V) over dotO(2). Under hypoxia, cerebral oxygenation progressively decreased as exercise workload increased. We found a strong correlation between increase in premotor time and decrease in cerebral oxygenation (r(2) = 0.89, P < 0.01), suggesting that increase in premotor time during exercise is associated with decrease in cerebral oxygenation. Accordingly, exercise at high altitude may compromise visual perceptual performance.