Identification of SNPs associated with susceptibility for development of adverse reactions to radiotherapy.
Identification of SNPs associated with susceptibility for development of adverse reactions to radiotherapy.
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DOI：
10.2217/pgs.10.186
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发表时间：
2011-02
期刊：
影响因子：
2.1
通讯作者：
Rosenstein BS
中科院分区：
文献类型：
--
作者：
Rosenstein BS
虽然放射治疗癌症可以产生高治愈率，但放射治疗往往会产生副作用。这些毒性表现为辐射场对正常组织和器官的损害。认识到个体对辐射的内在反应的实质性变化，大约10年前开始努力发现遗传标记，主要是SNP，其与对辐射治疗的这些不良反应的发展的易感性相关。这项研究的目的是确定SNPs，这些SNPs可以作为预测哪些癌症患者最有可能因放疗而发生并发症的分析的基础。这将允许个性化和优化每个癌症患者的治疗计划。
Although cancer treatment with radiation can produce high cure rates, adverse effects often result from radiotherapy. These toxicities are manifested as damage to normal tissues and organs in the radiation field. In recognition of the substantial variation in the intrinsic response of individuals to radiation, an effort began approximately 10 years ago to discover the genetic markers, primarily SNPs, which are associated with susceptibility for the development of these adverse responses to radiation therapy. The goal of this research is to identify the SNPs that could serve as the basis of an assay to predict which cancer patients are most likely to develop complications resulting from radiotherapy. This would permit personalization and optimization of the treatment plan for each cancer patient.
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影响因子：
3.6
作者：
Edvardsen, Hege;Tefre, Toril;Jansen, Laila;Vu, Phuong;Haffty, Bruce G.;Fossa, Sophie D.;Kristensen, Vessela N.;Borresen-Dale, Anne-Lise
通讯作者：
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DOI：
10.1016/j.ijrobp.2009.09.040
发表时间：
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影响因子：
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DOI：
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发表时间：
2005-07-15
影响因子：
7
作者：
De Ruyck, K;Van Eijkeren, M;Thierens, H
通讯作者：
Thierens, H
DOI：
10.1016/j.ijrobp.2006.03.047
发表时间：
2006-07-15
影响因子：
7
作者：
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通讯作者：
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DOI：
10.1016/j.ijrobp.2009.08.076
发表时间：
2010-03-01
影响因子：
7
作者：
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通讯作者：
Rosenstein, Barry S.