Photoinducible phase-specific light induction of Cry1 gene in the pars tuberalis of Japanese quail
Photoinducible phase-specific light induction of Cry1 gene in the pars tuberalis of Japanese quail
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DOI：
10.1210/en.2003-1285
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发表时间：
2004-04-01
期刊：
影响因子：
4.8
通讯作者：
Yoshimura, T
中科院分区：
文献类型：
--
作者：
Yasuo, S;Watanabe, M;Yoshimura, T
哺乳动物和鸟类催乳素（PRL）的分泌受光周期的调节。在哺乳动物中，垂体的结节部（PT）参与调节PRL分泌的光周期调节。然而，在鸟类中，下丘脑血管活性肠肽参与PRL分泌，而鸟类PT的生理作用仍不清楚。在本研究中，我们表明，PRL分泌增加下长日和短日与夜间中断的时间表，这两个也导致性腺生长在日本鹌鹑。我们还发现Cry1基因在日本鹌鹑PT中表达。Cry1在PT中的表达在长和短光周期下具有节律性，并且在延长的光周期下峰值延迟。此外，Cry1基因的表达诱导的光脉冲，但只有当在光诱导阶段。在我们以前的研究中，我们已经显示了节奏Per2基因表达的峰值在PT在早期的一天在不同的光周期。结合本研究的结果，不同光周期下日本鹌鹑PT中Per2和Cry1之间的不同相位关系可能会解码光周期信息，并以类似于哺乳动物的方式调节光周期PRL分泌。
Prolactin (PRL) secretion is regulated by photoperiod in mammals and birds. In mammals, the pars tuberalis ( PT) in the pituitary is involved in the regulation of photoperiodic regulation of PRL secretion. In birds, however, hypothalamic vasoactive intestinal peptide is implicated in PRL secretion, and physiological roles of the avian PT remain unknown. In the present study, we show that PRL secretion increases under long days and short days with a night interruptive schedule, both of which also cause gonadal growth in Japanese quail. We have also found Cry1 gene expression in the PT of Japanese quail. Cry1 expression was rhythmic under long and short photoperiods in the PT, and the peak was phase delayed under a lengthened photoperiod. Moreover, expression of Cry1 gene was induced by a light pulse but only when given during the photoinducible phase. In our previous study, we have shown rhythmic Per2 gene expression with a peak in the PT during the early day under various photoperiods. When taken together with the results from the present study, different phase relationships between Per2 and Cry1 in the Japanese quail PT under different photoperiods may decode photoperiodic information and regulate photoperiodic PRL secretion in a manner similar to that of mammals.