Building it up and taking it down: the regulation of vertebrate ciliogenesis.
Building it up and taking it down: the regulation of vertebrate ciliogenesis.
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DOI：
10.1002/dvdy.21540
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发表时间：
2008-08
影响因子：
2.5
通讯作者：
Reiter, Jeremy F.
中科院分区：
文献类型：
--
作者：
Santos, Nicole;Reiter, Jeremy F.
初级纤毛从大多数脊椎动物细胞表面伸出，在发育和成体组织动态平衡过程中发挥感觉和信号作用。越来越多的证据将纤毛缺陷与各种疾病联系起来，强调了了解这些动态细胞器是如何组装和维护的重要性。然而，尽管它们与生理和临床相关，调控纤毛发生的逻辑和机制在很大程度上仍然是个谜。在这里，我们总结了将初级纤毛的组装和拆解与细胞周期进展联系起来的新数据，并研究了细胞结构的决定因素，包括平面细胞极性途径，如何调控纤毛发生。此外，鉴定人类患者各种纤毛疾病的基因有助于揭示这种复杂细胞器的形成规律。
Primary cilia project from the surface of most vertebrate cells, and function in sensation and signaling during both development and adult tissue homeostasis. Mounting evidence links ciliary defects with a wide variety of diseases, underscoring the importance of understanding how these dynamic organelles are assembled and maintained. However, despite their physiological and clinical relevance, the logic and machinery that regulate ciliogenesis remain largely enigmatic. Here, we summarize emerging data that connect the assembly and disassembly of the primary cilium to cell cycle progression and we examine how determinants of cell architecture, including the planar cell polarity pathway, may regulate ciliogenesis. Additionally, identification of the genes underlying diverse ciliopathies in human patients is shedding light on the regulation of the formation of this complex organelle.
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影响因子：
21.3
作者：
Habedanck, R;Stierhof, YD;Nigg, EA
通讯作者：
Nigg, EA
影响因子：
30.8
作者：
Gerdes, Jantje M.;Liu, Yangfan;Katsanis, Nicholas
通讯作者：
Katsanis, Nicholas
DOI：
10.1083/jcb.147.1.71
发表时间：
1999-10-04
期刊：
The Journal of cell biology
影响因子：
--
作者：
Fan H;Khavari PA
通讯作者：
Khavari PA
影响因子：
21.3
作者：
Hergovich, A;Lisztwan, J;Krek, W
通讯作者：
Krek, W
影响因子：
9.8
作者：
Baala, Lekbir;Romano, Stephane;Attie-Bitach, Tania
通讯作者：
Attie-Bitach, Tania