Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study
Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study
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DOI：
10.1016/j.nbd.2008.08.001
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发表时间：
2008-12-01
影响因子：
6.1
通讯作者：
Brooks, David J.
中科院分区：
文献类型：
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作者：
Edison, Paul;Archer, Hilary A.;Brooks, David J.
[11 C]（R）PK 11195-PET是活化小胶质细胞的标志物，而[11 C]PIB-PET检测淀粉样蛋白负荷升高。本文研究了阿尔茨海默病（Alzheimer 'sdisease，AD）患者脑内淀粉样蛋白负荷和小胶质细胞活化的分布及其与认知功能的关系。13例AD受试者接受了[11 C]（R）PK 11195-PET和[11 C] PIB-PET扫描。10名健康对照者进行了[11 CI（R）PK]1195-PET扫描，14名对照者进行了[11 C]PIB-PET扫描。[11 C]（R）PK 11195-PET的感兴趣区域分析检测到额叶、颞叶、顶叶、枕叶和扣带皮质的小胶质细胞活化显著增加20-35%（p
[11C](R)PK11195-PET is a marker of activated microglia while [11C]PIB-PET detects raised amyloid load. Here we studied in vivo the distributions of amyloid load and microglial activation in Alzheimer's disease (AD) and their relationship with cognitive status. Thirteen AD subjects had [11C](R)PK11195-PET and [11C]PIB-PET scans. Ten healthy controls had [11CI(R)PK]1195-PET and 14 controls had [11C]PIB-PET scans. Region-of-interest analysis of [11C](R)PK11195-PET detected significant 20-35% increases in microglial activation in frontal, temporal, parietal, occipital and cingulate cortices (p