Express and protect yourself: The potential role of HLA-G on muscle cells and in inflammatory myopathies
Express and protect yourself: The potential role of HLA-G on muscle cells and in inflammatory myopathies
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DOI：
10.1016/j.humimm.2003.07.001
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发表时间：
2003-11-01
期刊：
影响因子：
2.7
通讯作者：
Weller, M
中科院分区：
文献类型：
--
作者：
Wiendl, H;Mitsdoerffer, M;Weller, M
在许多疾病中，肌肉是免疫损伤的部位或目标。在生理条件下，肌纤维对主要组织相容性复合体（MHC） I类抗原是阴性的，而在病理条件下，这些抗原上调，从而使肌肉成为细胞毒性CD8 T细胞识别的可能目标。培养的肌肉细胞能够将抗原呈递给CD4和CD8 T细胞，进一步表明体内肌肉纤维在炎症反应的启动或持续步骤中起着关键作用。自身免疫性炎症性肌病的肌纤维在体内和体外培养的肌肉细胞中表达非经典的主要组织相容性复合体分子HLA-G，这一发现提出了关于其可能的病理生理作用的几个假设。我们回顾了目前关于肌肉相关HLA-G功能后果的知识，并提供了其在病理条件下相关的概念。我们进一步推测HLA-G的潜在治疗意义，涉及到特殊的方法，如成肌细胞移植或对抗炎症攻击的策略。人类免疫学64,1050-1056（2003）。(C)美国组织相容性与免疫遗传学学会，2003。Elsevier Inc.出版。
Muscle is the site or the target of immunologic injury in several diseases. Whereas under physiologic conditions muscle fibers are negative for major histocompatibility complex (MHC) class I antigens, these are upregulated under pathologic conditions, thus rendering muscle a possible target for the recognition by cytotoxic CD8 T cells. Cultured muscle cells are capable of presenting antigens to CD4 and CD8 T cells, further indicating that muscle fibers in vivo are critically involved in the initiating or perpetuating steps of inflammatory responses. The finding that muscle fibers in autoimmune inflammatory myopathies in vivo and cultured muscle cells in vitro express the nonclassical major histocompatibility complex molecule HLA-G raises several hypothesis concerning its possible pathophysiologic role. We review present knowledge on the functional consequences of muscle-related HLA-G and provide concepts of its relevance under pathologic conditions. We further speculate on the potential therapeutic implications of HLA-G that relate to special approaches such as myoblast transplantation or strategies against inflammatory aggression in general. Human Immunology 64, 1050-1056 (2003). (C) American Society for Histocompatibility and Immunogenetics, 2003. Published by Elsevier Inc.