Gabapentin dose and the 30-day risk of altered mental status in older adults: A retrospective population-based study
Gabapentin dose and the 30-day risk of altered mental status in older adults: A retrospective population-based study
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DOI：
10.1371/journal.pone.0193134
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发表时间：
2018-03-14
期刊：
影响因子：
3.7
通讯作者：
Garg, Amit X.
中科院分区：
文献类型：
--
作者：
Fleet, Jamie L.;Dixon, Stephanie N.;Garg, Amit X.
加巴喷丁是治疗慢性神经性疼痛的有效药物，但在一些老年人中可能引起头晕、嗜睡和精神错乱。本研究的目的是评估加巴喷丁剂量与不良结局之间的关系，通过获得加拿大安大略省老年人（平均年龄76岁）在高剂量（bbb600 mg/天；n = 34,159）与低剂量(
Gabapentin is an effective treatment for chronic neuropathic pain but may cause dizziness, drowsiness, and confusion in some older adults. The goal of this study was to assess the association between gabapentin dosing and adverse outcomes by obtaining estimates of the 30-day risk of hospitalization with altered mental status and mortality in older adults (mean age 76 years) in Ontario, Canada initiated on high dose (>600 mg/day; n = 34,159) compared to low dose (