Impact of phenolic-rich olive leaf extract on blood pressure, plasma lipids and inflammatory markers: a randomised controlled trial.
Impact of phenolic-rich olive leaf extract on blood pressure, plasma lipids and inflammatory markers: a randomised controlled trial.
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DOI：
10.1007/s00394-016-1188-y
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发表时间：
2017-06
影响因子：
5
通讯作者：
Stonehouse W
中科院分区：
文献类型：
--
作者：
Lockyer S;Rowland I;Spencer JPE;Yaqoob P;Stonehouse W
膳食多酚已被证明可以有利地改变许多心血管风险标志物，如血压（BP），内皮功能和血脂。我们进行了一项随机、双盲、对照、交叉试验，以研究富含酚类的橄榄叶提取物（OLE）对血压和许多相关血管和代谢指标的影响。 共60例高血压前期[收缩压（SBP）：121-140 mmHg;舒张压（DBP）：81-90 mmHg]男性[平均年龄45岁（±SD 12.7岁，BMI 26.7（±3.21）kg/m2）（136 mg橄榄苦苷; 6 mg羟基酪醇）或无多酚对照，持续6周，然后在4周洗脱后转换至替代组。白天[-3.95（±SD 11.48）mmHg，p = 0.027]和24小时SBP [-3.33（±SD 10.81）mmHg，p = 0.045]和日间和24小时DBP [-3.00（±SD 8.54）mmHg，p = 0.025; −2.42（±SD 7.61）mmHg，p = 0.039]在摄入OLE后均显著低于对照组。降低血浆总胆固醇[-0.32（±SD 0.70）mmol/L，p = 0.002]，LDL胆固醇[−0.19（±SD 0.56）mmol/L，p = 0.017]和甘油三酯[-0.18（±SD 0.48），p = 0.008]，同时还检测到白细胞介素-8减少[-0.63（±SD 1.13）pg/ml; p = 0.026]。其他炎症标志物、血管功能和葡萄糖代谢不受影响。我们的数据支持以前的研究，表明OLE摄入量在体内产生消肿和降脂作用。本文的在线版本（doi：10.1007/s 00394 -016-1188-y）包含补充材料，可供授权用户使用。
Dietary polyphenols have been demonstrated to favourably modify a number of cardiovascular risk markers such as blood pressure (BP), endothelial function and plasma lipids. We conducted a randomised, double-blind, controlled, crossover trial to investigate the effects of a phenolic-rich olive leaf extract (OLE) on BP and a number of associated vascular and metabolic measures. A total of 60 pre-hypertensive [systolic blood pressure (SBP): 121–140 mmHg; diastolic blood pressure (DBP): 81–90 mmHg] males [mean age 45 (±SD 12.7 years, BMI 26.7 (±3.21) kg/m2] consumed either OLE (136 mg oleuropein; 6 mg hydroxytyrosol) or a polyphenol-free control daily for 6 weeks before switching to the alternate arm after a 4-week washout. Daytime [−3.95 (±SD 11.48) mmHg, p = 0.027] and 24-h SBP [−3.33 (±SD 10.81) mmHg, p = 0.045] and daytime and 24-h DBP [−3.00 (±SD 8.54) mmHg, p = 0.025; −2.42 (±SD 7.61) mmHg, p = 0.039] were all significantly lower following OLE intake, relative to the control. Reductions in plasma total cholesterol [−0.32 (±SD 0.70) mmol/L, p = 0.002], LDL cholesterol [−0.19 (±SD 0.56) mmol/L, p = 0.017] and triglycerides [−0.18 (±SD 0.48), p = 0.008] were also induced by OLE compared to control, whilst a reduction in interleukin-8 [−0.63 (±SD 1.13) pg/ml; p = 0.026] was also detected. Other markers of inflammation, vascular function and glucose metabolism were not affected. Our data support previous research, suggesting that OLE intake engenders hypotensive and lipid-lowering effects in vivo. The online version of this article (doi:10.1007/s00394-016-1188-y) contains supplementary material, which is available to authorized users.