Comparative bone healing near eroding polylactide-polyglycolide implants of differing crystallinity in rabbit tibial bone chambers.
Comparative bone healing near eroding polylactide-polyglycolide implants of differing crystallinity in rabbit tibial bone chambers.
复制标题
兔胫骨骨室中不同结晶度的侵蚀聚丙交酯-聚乙交酯植入物附近的骨愈合比较。
DOI：
10.1163/156856297x00425
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Bao,JY
中科院分区：
文献类型：
--
作者：
Winet,H;Bao,JY
在骨室胫骨植入物（BCI）中加载后，在体内长期观察到聚（DL-丙交酯-共-乙交酯）（PDLLG）垫圈和聚（L-丙交酯-共-乙交酯）（PLLG）线的侵蚀。使用植入兔子的活体显微镜记录图像。以血管生成和骨生成为代表的侵蚀和骨愈合分别通过观察到的聚合物、血管和骨的投影面积的变化来确定。两种聚合物的侵蚀速率显着不同。两种聚合物附近的愈合情况与对照组有显着差异。 对每种聚合物的愈合反应也不同，与 PLLG 相比，侵蚀速度更快的 PDLLG 导致更多偏离正常骨生成和血管生成。据推测，侵蚀速度较快的聚合物在愈合过程中较早释放出巨噬细胞刺激片段，从而改变了正常的巨噬细胞-内皮细胞相互作用，进而影响了与血管生成相关的成骨成分。
Eroding poly(DL-lactide-co-glycolide) (PDLLG) washers and poly(L-lactide-co-glycolide) (PLLG) threads were observed chronically in vivo following loading in a bone chamber tibial implant (BCI). Images were recorded using intravital microscopy of the implanted rabbit. Erosion and bone healing, as represented by angiogenesis and osteogenesis, was determined from changes in projected area of observed polymer, vessels and bone, respectively. Erosion rates of the two polymers were significantly different. Healing adjacent to both polymers differed significantly from controls. Healing response to each polymer was also different, with the faster eroding PDLLG causing more deviation from normal osteogenesis and angiogenesis than did PLLG. It was speculated that the faster eroding polymer released macrophage-stimulating fragments earlier in the healing process, thus altering the normal macrophage-endothelial cell interaction which in turn affected angiogenesis-linked components of osteogenesis.