Permeability of rabbit skin and muscle microvasculature after saline infusion.
Permeability of rabbit skin and muscle microvasculature after saline infusion.
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输注盐水后兔皮肤和肌肉微血管的渗透性。
DOI：
10.1016/0022-4804(82)90118-4
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Bell,DR
中科院分区：
文献类型：
--
作者：
Mullins,RJ;Bell,DR
用相当于体重9.5%的生理盐水灌注家兔，观察其皮肤和骨骼肌微血管的蛋白质渗透特性。从这两种组织中收集结前淋巴液。在肌肉中，淋巴流量从基线的0.94 ± 0.12增加至2：91 ± 0.36微升（μl）/min，淋巴-血浆总蛋白比（RT）从0.561 ± 0.033降低至0.364 ± 0.016。皮肤淋巴流量从1.56 ± 0.25 μl/min增加到4.01 ± 0.64 μ l/min，RT从0.340 ± 0.014下降到0.230 ± 0.016。在两种组织中，白蛋白的淋巴细胞/血浆比均大于对照组中免疫球蛋白G的淋巴细胞/血浆比，并且在输注后显示出相同的关系。因此，膜选择性和蛋白质筛分不随血浆体积的盐水膨胀而改变。大量静脉输注晶体液后，这些组织（包含70%的间质体积）的微血管通透性未发生变化。
The protein permeability characteristics of skin and skeletal muscle microvasculature were examined in rabbits following saline infusion equivalent to 9.5% of the body weight. Prenodal lymph was collected from these two tissues. In muscle the lymph flow increased from 0.94 ± 0.12 to 2:91 ± 0.36 microliters (μl)/min over baseline, and the lymph-to-plasma total protein ratio (RT) decreased from 0.561 ± 0.033 to 0.364 ± 0.016. In skin the lymph flow increased from 1.56 ± 0.25 to 4.01 ± 0.64 microliters (μl)/min, and theRTdecreased from 0.340 ± 0.014 to 0.230 ± 0.016. In both tissues, the lymph-to-plasma ratios for albumin were greater than those for immunoglobulin G in controls and showed the same relationship after infusion. Thus, membrane selectivity and protein sieving did not change with saline expansion of the plasma volume. No change in microvasculature permeability occurred in these tissues, which contain 70% of the interstitial volume, following a large intravenous infusion of crystalloid.