Update on therapy of atopic dermatitis
Update on therapy of atopic dermatitis
复制标题
DOI：
10.1016/s0091-6749(99)70054-0
复制
发表时间：
1999-09-01
影响因子：
14.2
通讯作者：
Tofte, SJ
中科院分区：
文献类型：
--
作者：
Hanifin, JM;Tofte, SJ
特应性皮炎（AD）是一种复杂的疾病，通常难以治疗。有效的治疗通常受到3种矛盾的阻碍：（1）皮肤护理与过敏治疗的优先顺序;（2）对最佳沐浴和保湿的不确定性;（3）对使用适当的局部皮质类固醇治疗犹豫不决。通过自信、精心策划的方法，可以实现有效的治疗管理。在初步评估时，评估表是一种工具，用于重点关注对诊断至关重要的重要病史和身体特征，并审查触发因素和既往治疗。必须教育患者和父母，使他们更加了解可能导致疾病恶化的触发因素。沐浴和保湿中的错误是持续性AD的主要原因，并且必须解决水对皮肤既好又坏的混淆游行以实现治疗成功。关于局部类固醇使用的建议的避免/方法冲突对患者结果具有不利影响。随着中等强度局部药剂的适当使用以及最近开发的用于AD的局部大环内酯类，可以实现对该病的有效管理。
Atopic dermatitis (AD) is complicated and often difficult to manage. Effective therapy is commonly impeded by 3 ambivalencies: (1) prioritization of skin care versus allergy treatment; (2) uncertainty about optimal bathing and moisturizing, and (3) hesitation about the use of adequate topical corticosteroid therapies. With a confident, well-planned approach, effective therapy management may be achieved. On initial assessment, an evaluation form is a tool to keep the focus on important history and physical features critical for the diagnosis and to review trigger factors and past therapies. Patients and parents must be educated to become more aware of the trigger factors that may lead to an exacerbation of their disease. Errors in bathing and moisturizing are the major cause of persistent AD, and the confusing parades that water is both good and bad for the skin must be resolved to achieve therapeutic success, Avoidance/approach conflicts regarding recommendations of topical steroid use has a detrimental effect on patient outcomes, With the proper use of mid-strength topical agents and with the recent development of topical macrolides for use in AD, effective management for this disease can be realized.