Working across the veterinary and human health sectors
Working across the veterinary and human health sectors
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DOI：
10.1093/jac/dks206
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发表时间：
2012-07-01
影响因子：
5.2
通讯作者：
Hawkey, Peter
中科院分区：
文献类型：
--
作者：
Garcia-Alvarez, Laura;Dawson, Susan;Hawkey, Peter
抗生素广泛应用于人类和兽医领域，用于预防和治疗传染病。这种做法导致人类和动物体内出现了耐药细菌。动物，特别是牲畜，作为抗生素抗性基因的潜在储存库的潜在作用已得到认识，目前已引起公众健康关注。动物和人类抗生素的使用对耐药细菌的出现和持久性的影响以及人类和动物之间耐药基因的精确转移途径目前尚未完全了解。作为英国抗菌素耐药性和医疗相关感染咨询委员会 (ARHAI) 职责的一部分，解决了两个主要领域，即耐甲氧西林金黄色葡萄球菌 (MRSA) 和多重耐药革兰氏阴性菌，人类和兽医卫生部门在这两个领域都有共同利益。我们回顾了 MRSA 和耐药革兰氏阴性菌的最新知识，并为与感染或定植 MRSA 的动物相关的兽医保健工作者提供职业风险指导。还提出了跨学科进一步工作以及多重耐药革兰氏阴性菌未来研究的发现和建议。为了更好地理解和挑战重要的人类和动物健康问题：抗菌素耐药性，跨学科合作至关重要。
Antibiotics are widely used in human and veterinary medicine for the prevention and treatment of infectious diseases. This practice has led to the emergence of antimicrobial-resistant bacteria in both humans and animals. The potential role that animals, particularly livestock, might play as potential reservoirs of antibiotic resistance genes has been recognized, and it is currently a cause of public health concern. The impact of animal and human antibiotic usage on the emergence and persistence of resistant bacteria and the precise transfer pathways for resistance genes between humans and animals are not currently fully understood. As part of the remit of the UK Advisory Committee on Antimicrobial Resistance and Healthcare-Associated Infection (ARHAI), two main areas were addressed, namely methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant Gram-negative bacteria, where both the human and veterinary health sectors share interests. We review the current knowledge of MRSA and resistant Gram-negative bacteria, and provide guidance on occupational risks for veterinary healthcare workers relating to animals infected or colonized with MRSA. Findings and recommendations for further work across disciplines and future research in multidrug-resistant Gram-negative bacteria are also presented. Working collaboratively across disciplines is essential in order to better understand and challenge an important human and animal health problem: antimicrobial resistance.