Increased Systemic Cytokine/Chemokine Expression in Asthmatic and Non-asthmatic Patients with Bacterial, Viral or Mixed Lung Infection
Increased Systemic Cytokine/Chemokine Expression in Asthmatic and Non-asthmatic Patients with Bacterial, Viral or Mixed Lung Infection
复制标题
细菌、病毒或混合性肺部感染的哮喘和非哮喘患者的系统性细胞因子/趋化因子表达增加
DOI：
10.1111/sji.12532
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发表时间：
2017-04-01
影响因子：
3.7
通讯作者：
Alvarez-Mon, M.
中科院分区：
文献类型：
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作者：
Giuffrida, M. J.;Valero, N.;Alvarez-Mon, M.
本研究旨在探讨急性呼吸道细菌、病毒或混合感染的哮喘患者与非哮喘患者血清细胞因子(IL-1β、TNFα、IL-4、IL-5)和趋化因子(MCP-1：单核细胞趋化蛋白-1和RANTES：活化正常T细胞表达和分泌的调节)的变化。对14例喘息型和29例非喘息型急性病毒、细菌或混合(细菌和病毒)呼吸道感染患者进行研究。患者也被分析为肺炎或支气管炎的个体。对照组为年龄、性别相近的健康人(n=10)。采用双抗体夹心法测定血清细胞因子/趋化因子含量。哮喘患者和非哮喘患者细胞因子/趋化因子浓度升高。然而，被病毒、细菌或细菌和病毒(混合)感染的哮喘患者的趋化因子(MCP-1和RANTES)浓度高于非哮喘患者。总的来说，病毒感染和混合感染是比细菌感染更好的细胞因子/趋化因子诱导剂。在肺炎或支气管炎的哮喘和非哮喘患者中，细胞因子/趋化因子的表达同样增加，只是支气管炎患者的RANTES保持在正常水平。急性病毒、细菌或混合肺部感染诱导的循环细胞因子谱与哮喘背景无关，除了在哮喘状态下趋化因子增加。
This study was aimed to determine the profiles of serum cytokines (IL-1 beta, TNF alpha, IL-4, IL-5) and chemokines (MCP-1: monocyte chemoattract protein-1 and RANTES: regulated on activation normal T cell expressed and secreted) in individuals with an asthmatic versus a non-asthmatic background with bacterial, viral or mixed acute respiratory infection. Asthmatic (n = 14) and non-asthmatic (n = 29) patients with acute viral, bacterial or mixed (bacterial and viruses) respiratory infection were studied. Patients were also analysed as individuals with pneumonia or bronchitis. Healthy individuals with similar age and sex (n = 10) were used as controls. Cytokine/ chemokine content in serum was determined by ELISA. Increased cytokine/ chemokine concentration in asthmatic and nonasthmatic patients was observed. However, higher concentrations of chemokines (MCP-1 and RANTES) in asthmatic patients infected by viruses, bacteria or bacteria and viruses (mixed) than in non-asthmatic patients were observed. In general, viral and mixed infections were better cytokine/ chemokine inducers than bacterial infection. Cytokine/ chemokine expression was similarly increased in both asthmatic and non-asthmatic patients with pneumonia or bronchitis, except that RANTES remained at normal levels in bronchitis. Circulating cytokine profiles induced by acute viral, bacterial or mixed lung infection were not related to asthmatic background, except for chemokines that were increased in asthmatic status.