MR Imaging in Ataxias: Consensus Recommendations by the Ataxia Global Initiative Working Group on MRI Biomarkers.
MR Imaging in Ataxias: Consensus Recommendations by the Ataxia Global Initiative Working Group on MRI Biomarkers.
复制标题
共济失调中的 MR 成像：共济失调全球倡议 MRI 生物标志物工作组的共识建议。
DOI：
10.1007/s12311-023-01572-y
复制
发表时间：
2023
期刊：
影响因子：
--
通讯作者：
AGIWorkingGrouponMRIBiomarkers
中科院分区：
文献类型：
--
作者：
Öz,Gülin;Cocozza,Sirio;Henry,Pierre-Gilles;Lenglet,Christophe;Deistung,Andreas;Faber,Jennifer;Schwarz,AdamJ;Timmann,Dagmar;VanDijk,KoeneRA;Harding,IanH;AGIWorkingGrouponMRIBiomarkers
随着许多可行的治疗策略，即将进行的遗传性和散发性退行性共济失调的临床试验将受益于非侵入性MRI生物标志物，用于患者分层和治疗评估。因此，共济失调全球倡议的MRI生物标志物工作组制定了指导方针，以促进共济失调临床研究和试验中协调的MRI数据采集。提供了可用于临床护理的基本结构MRI方案以及与研究和试验设置相关的高级多模式MRI方案的建议。先进的协议包括模式与证明效用的退行性共济失调的大脑变化跟踪，包括结构MRI，磁共振波谱，扩散MRI，定量磁敏感性映射，和静息状态功能MRI。提供了可接受的采集参数范围，以适应研究和临床环境中的各种扫描仪硬件，同时保持最低的数据质量标准。在建立一个先进的多模态协议的重要技术考虑事项进行了概述，包括脉冲序列的顺序，并提供了通常用于数据分析的示例软件包。与共济失调最相关的结果测量与最近共济失调文献的用例一起突出显示。最后，为了便于共济失调临床和研究社区获得建议，提供了使用建议参数收集的数据集示例，并通过开放科学框架共享特定于平台的协议。
With many viable strategies in the therapeutic pipeline, upcoming clinical trials in hereditary and sporadic degenerative ataxias will benefit from non-invasive MRI biomarkers for patient stratification and the evaluation of therapies. The MRI Biomarkers Working Group of the Ataxia Global Initiative therefore devised guidelines to facilitate harmonized MRI data acquisition in clinical research and trials in ataxias. Recommendations are provided for a basic structural MRI protocol that can be used for clinical care and for an advanced multi-modal MRI protocol relevant for research and trial settings. The advanced protocol consists of modalities with demonstrated utility for tracking brain changes in degenerative ataxias and includes structural MRI, magnetic resonance spectroscopy, diffusion MRI, quantitative susceptibility mapping, and resting-state functional MRI. Acceptable ranges of acquisition parameters are provided to accommodate diverse scanner hardware in research and clinical contexts while maintaining a minimum standard of data quality. Important technical considerations in setting up an advanced multi-modal protocol are outlined, including the order of pulse sequences, and example software packages commonly used for data analysis are provided. Outcome measures most relevant for ataxias are highlighted with use cases from recent ataxia literature. Finally, to facilitate access to the recommendations by the ataxia clinical and research community, examples of datasets collected with the recommended parameters are provided and platform-specific protocols are shared via the Open Science Framework.