Previous treatment predicts the efficiency of blood progenitor cell mobilisation: validation of a chemotherapy scoring system
Previous treatment predicts the efficiency of blood progenitor cell mobilisation: validation of a chemotherapy scoring system
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DOI：
10.1038/sj.bmt.1701461
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发表时间：
1998-11-01
影响因子：
4.8
通讯作者：
Brammer, CG
中科院分区：
文献类型：
--
作者：
Clark, RE;Brammer, CG
在动员化疗和骨髓生长因子后，一些重度预治疗的患者不能动员足够数量的外周血祖细胞（PBPC）。提前识别这些患者将是临床上有用的。最近的评分系统的基础上以前的治疗可能是有用的预测CD 34阳性细胞产量。在这项研究中，我们验证了一个独立的99名患者接受103个收获事件的评分系统。在61例接受环磷酰胺1.5 g/m2和G-CSF动员的患者中，治疗评分小于21的患者产生的CD 34阳性细胞显著多于评分大于63的患者（P = 0.0012）。既往接受美法仑或卡莫司汀治疗与CD 34阳性细胞产量显著降低相关（P = 0.0001）。既往放化疗时间与收获结果之间无相关性。治疗评分小于21分的患者需要更短的G-CSF治疗时间（P = 0.05）。在采用替代动员时间表进行的42个进一步动员周期中也观察到了类似的结果。目前的数据表明，总结既往治疗的评分可用于预测CD 34产量，并可用于临床提前识别不良PBPC动员剂。
Following mobilising chemotherapy and myeloid growth factors, some heavily pretreated patients do not mobilise adequate numbers of peripheral blood progenitor cells (PBPC). It would be clinically useful to identify such patients in advance. A recent scoring system based on previous therapy may be useful in predicting CD34-positive cell yield. In this study we validated this scoring system on an independent group of 99 patients undergoing 103 harvesting episodes. In 61 patients mobilised with cyclophosphamide 1.5 g/m(2) and G-CSF, those with treatment scores less than 21 yielded significantly more CD34-positive cells than patients with scores greater than 63 (P = 0.0012). Previous treatment with melphalan or carmustine was associated with a significantly lower yield of CD34-positive cells (P = 0.0001). No relationship was seen between the time from previous chemoradiotherapy and harvest outcome. Patients with treatment scores less than 21 required a shorter duration of G-CSF therapy (P = 0.05). Similar findings were seen in 42 further mobilisation cycles undertaken with alternative mobilisation schedules. The present data suggest that a score summarising previous treatment can be used to predict CD34 yields, and could be of clinical use to identify poor PBPC mobilisers in advance.