Lack of association between ADAM33 gene and asthma in a Chinese population
Lack of association between ADAM33 gene and asthma in a Chinese population
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DOI：
10.1111/j.1744-313x.2006.00617.x
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发表时间：
2006-08
影响因子：
2.2
通讯作者：
Peng George Wang;Qiji Liu;Jiangxia Li;H. C. Li;C. H. Wei;Chenhong Guo;Yaoqin Gong
中科院分区：
文献类型：
--
作者：
Peng George Wang;Qiji Liu;Jiangxia Li;H. C. Li;C. H. Wei;Chenhong Guo;Yaoqin Gong
哮喘是一种复杂的多基因疾病，基因-环境相互作用是重要的。先前已经提出，ADAM 33是编码具有去整合素和金属蛋白酶结构域的膜锚定蛋白的基因家族的成员，主要在肺成纤维细胞和支气管平滑肌细胞中表达，并且与气道重塑和支气管高反应性相关。先前已经证明在不同种族人群中，ADAM 33的单核苷酸多态性（SNP）和单倍型与哮喘之间存在显著关联。为了评估中国汉族人群中ADAM 33的SNPs或单倍型是否与哮喘相关，我们在一项病例对照研究中对296例哮喘患者和270例健康对照进行了ADAM 33的3个SNPs（内含子6中的7575 G/A，内含子19中的11188 A/T和外显子20中的12433 T/C）的基因分型。在中国人群中，这三个SNP与哮喘易感性之间未检测到显著关联。
Asthma is a complex polygenic disease with gene–environment interactions being important. It has been previously suggested that ADAM33, which is a member of a gene family that encodes membrane‐anchored proteins with a disintegrin and a metalloprotease domain, is primarily expressed in lung fibroblasts and bronchial smooth muscle cells and has been associated with airway remodelling and bronchial hyperresponsiveness. A significant association has previously been demonstrated between single nucleotide polymorphisms (SNPs) and haplotypes of the ADAM33 and asthma in ethnically diverse populations. To assess whether SNPs or haplotypes of ADAM33 are related to asthma in a Chinese Han population, we genotyped three SNPs of ADAM33 (7575G/A in intron 6, 11188A/T in intron 19, and 12433T/C in exon 20) in a case‐control study involving 296 patients with asthma and 270 healthy controls. No significant association was detected between these three SNPs and asthma susceptibility in the Chinese population.