Outcome of pregnancies complicated by ruptured membranes after genetic amniocentesis
Outcome of pregnancies complicated by ruptured membranes after genetic amniocentesis
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DOI：
10.1067/mob.2000.108872
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发表时间：
2000-10-01
影响因子：
9.8
通讯作者：
Egan, JFX
中科院分区：
文献类型：
--
作者：
Borgida, AF;Mills, AA;Egan, JFX
目的：我们试图比较遗传性羊膜穿刺术后并发胎膜早破的妊娠与相似胎龄并发自发性胎膜早破的妊娠的围产期结局。 研究设计：进行了一项回顾性研究，其中审查了计算机化数据库，以识别从 7 月份起在遗传性羊膜穿刺术后 48 小时内到我们机构就诊的所有患有胎膜早破的患者。 1988 年至 1999 年 8 月。对照受试者在胎膜早破时匹配胎龄。患者都得到了预期的管理，结果是根据病历审查得出的。采用描述性统计、Student t检验和chi(2)检验，P < .05认为显着。 结果：在研究期间，进行了1101次遗传性羊膜穿刺术。 11 名 (1%) 女性在 48 小时内出现胎膜早破。遗传性羊膜穿刺术后发生早产胎膜早破的病例与自然发生早产胎膜早破的对照组相比，破裂时的平均胎龄没有差异（分别为16.5周和17.6周）。与自发性早产胎膜早破的女性相比，羊膜穿刺术后早产胎膜早破的女性的潜伏期明显更长（124 天 vs 28 天；P = .0001），且胎龄更高（34.2 vs 21.6 周；P = .0002）。基因羊膜穿刺术后并发胎膜早破的妊娠围产儿存活率为 91%，而对照受试者的围产期存活率为 9% (P = .005)。 结论：与相似胎龄并发自发性胎膜早破的妊娠相比，基因羊膜穿刺术后并发胎膜早破的妊娠围产期结局明显更好。在这种情况下应考虑预期治疗。
OBJECTIVE: We sought to compare perinatal outcomes of pregnancies complicated by preterm premature rupture of membranes after genetic amniocentesis with pregnancies complicated by spontaneous preterm premature rupture of membranes at a similar gestational age.STUDY DESIGN: A retrospective study was performed in which a computerized database was reviewed to identify all patients presenting to our institution with preterm premature rupture of membranes within 48 hours of a genetic amniocentesis from July 1988 to August 1999. Control subjects were matched for gestational age at preterm premature rupture of membranes. Patients were all managed expectantly Outcomes were compiled from review of medical records. Descriptive statistics, the Student t test, and the chi (2) test were used, with P < .05 considered significant.RESULTS: During the study period, genetic amniocentesis was performed 1101 times. Eleven (1%) women presented within 48 hours with preterm premature rupture of membranes. The mean gestational age at the time of rupture was not different between the cases in which preterm premature rupture of membranes occurred after genetic amniocentesis compared with the control subjects in whom preterm premature rupture of membranes occurred spontaneously (16.5 weeks vs 17.6 weeks, respectively). Women with preterm premature rupture of membranes after amniocentesis experienced significantly longer latency periods (124 vs 28 days; P = .0001) and delivered at more advanced gestational ages (34.2 vs 21.6 weeks; P = .0002) than those with spontaneous preterm premature rupture of membranes. The perinatal survival rate was 91% in pregnancies complicated by preterm premature rupture of membranes after genetic amniocentesis compared with a rate of 9% in control subjects (P = .005).CONCLUSIONS: Pregnancies complicated by preterm premature rupture of membranes after genetic amniocentesis result in significantly better perinatal outcomes compared with pregnancies complicated by spontaneous preterm premature rupture of membranes at a similar gestational age. Expectant management should be considered in such cases.