Rate of over-diagnosis of breast cancer 15 years after end of Malmo mammographic screening trial: follow-up study
Rate of over-diagnosis of breast cancer 15 years after end of Malmo mammographic screening trial: follow-up study
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DOI：
10.1136/bmj.38764.572569.7c
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发表时间：
2006-03-25
影响因子：
--
通讯作者：
Garne, JP
中科院分区：
文献类型：
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作者：
Zackrisson, S;Andersson, I;Garne, JP
目的评估乳腺癌过度诊断率15年后结束的马尔莫乳腺X线摄影筛查试验。设计随访研究。设置马尔莫，瑞典。受试者42 283名妇女年龄在45-69岁的随机。干预筛查乳腺癌与乳腺X线摄影或不（对照）。在随机化设计结束时，对45-54岁的两组进行筛查，但不对55-69岁的两组进行筛查。（原位和侵入性），计算为随机化设计期间邀请组和对照组的发生率（阶段1），在阶段内随机化设计结束（第二阶段），结果在随机分组的55-69岁女性中，（95%置信区间）为1.32（1.14至1.53）对于第1期，0.92（0.79至1.06）对于周期2，和1.10（0.99 ~ 1.22）。在马尔莫乳房X线摄影筛查试验中，乳腺癌的诊断主要是在随机分组时年龄在55-69岁的妇女中得出的，而对照组从未接受过筛查。试验结束15年后，该年龄组的乳腺癌过度诊断率为10%。
Objective To evaluate the rate of over-diagnosis of breast cancer 15 years after the end of the Malmo mammographic screening trial.Design Follow-up Study.Setting Malmo, Sweden.Subjects 42 283 women aged 45-69 years at randomisation.Interventions Screening for breast cancer with mammography or not (controls). Screening was offered at end of randomisation design to both groups aged 45-54 at randomisation but not to groups aged 55-69 at randomisation.Main outcome measures Rate of over-diagnosis of breast cancer (in situ and invasive), calculated as incidence in the invited and control groups, during period of randomised design (period 1), during period randomised design ended (period 2), and at end of follow-up.Results In women aged 55-69 years at randomisation the relative rates of over-diagnosis of breast cancer (95% confidence intervals) were 1.32 (1.14 to 1.53) for period 1, 0.92 (0.79 to 1.06) for period 2, and 1.10 (0.99 to 1.22) at the end of follow-up.Conclusion Conclusions on over-diagnosis of breast cancer in the Malmo mammographic screening trial can be drawn mainly in women aged 55-69 years at randomisation whose control groups were never screened. Fifteen years after die trial ended the rate of over-diagnosis of breast cancer was 10% in this age group.