CASTp: Computed atlas of surface topography of proteins
CASTp: Computed atlas of surface topography of proteins
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DOI：
10.1093/nar/gkg512
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发表时间：
2003-07-01
影响因子：
14.9
通讯作者：
Liang, J
中科院分区：
文献类型：
--
作者：
Binkowski, TA;Naghibzadeh, S;Liang, J
CASTp （Computed Atlas of Surface Topography of proteins）为蛋白质三维结构的凹表面区域的定位、描绘和测量提供了一个在线资源。这些包括位于蛋白质表面的口袋和埋在蛋白质内部的空隙。通过溶剂可及表面模型（Richards’s曲面）和分子表面模型（Connolly’s曲面），以解析的方式计算出袋穴或空隙的面积和体积。CASTp可用于研究蛋白质的表面特征和功能区域。CASTp包括一个图形用户界面，灵活的交互式可视化，以及对用户上传的结构进行实时计算。CASTp每天更新，可访问http://cast.engr.uic.edu。
Computed Atlas of Surface Topography of proteins (CASTp) provides an online resource for locating, delineating and measuring concave surface regions on three-dimensional structures of proteins. These include pockets located on protein surfaces and voids buried in the interior of proteins. The measurement includes the area and volume of pocket or void by solvent accessible surface model (Richards' surface) and by molecular surface model (Connolly's surface), all calculated analytically. CASTp can be used to study surface features and functional regions of proteins. CASTp includes a graphical user interface, flexible interactive visualization, as well as on-the-fly calculation for user uploaded structures. CASTp is updated daily and can be accessed at http://cast.engr.uic.edu.