Retinal inner nuclear layer volume reflects response to immunotherapy in multiple sclerosis
Retinal inner nuclear layer volume reflects response to immunotherapy in multiple sclerosis
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DOI：
10.1093/brain/aww219
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发表时间：
2016-11-01
期刊：
影响因子：
14.5
通讯作者：
Korn, Thomas
中科院分区：
文献类型：
--
作者：
Knier, Benjamin;Schmidt, Paul;Korn, Thomas
多发性硬化症期间炎症性疾病活动的评估对于选择适当的疾病修饰疗法至关重要。先前的研究表明，视网膜内核层反映了中枢神经系统内炎症性疾病的严重程度。在我们的研究中，通过视网膜光学相干断层扫描测量的纵向视网膜层变化与正在进行的疾病活动的相关性在108例未治疗、一线治疗或二线治疗的多发性硬化症患者中进行了评估。健康受试者作为对照。基线时的内核层体积与随后12个月的临床旁疾病活动呈正相关。内核层的纵向变薄和总黄斑体积的增厚与炎症性疾病活动的减少有关。1年后内核层体积的减少表明炎症性疾病活动得到有效控制，包括“无疾病活动证据”。总之，视网膜内核层可以作为生物标志物，监测持续控制自身免疫性中枢神经系统炎症的治疗干预。
Assessment of inflammatory disease activity during multiple sclerosis is crucial for selecting appropriate disease- modifying therapies. Previous studies suggested that the retinal inner nuclear layer reflects inflammatory disease severity within the central nervous system. In our study, correlations of longitudinal retinal layer changes as measured by retinal optical coherence tomography with ongoing disease activity were evaluated in 108 multiple sclerosis patients without therapy, on first- line therapy, or on second- line therapy. Healthy subjects served as controls. Inner nuclear layer volume at baseline correlated positively with paraclinical disease activity during the subsequent 12 months. Longitudinal thinning of the inner nuclear layer and thickening of total macular volume were associated with reduced inflammatory disease activity. Reduction in inner nuclear layer volume after 1 year indicated efficient control of inflammatory disease activity including ` no evidence of disease activity'. In conclusion, the retinal inner nuclear layer could serve as biomarker to monitor sustained control of autoimmune central nervous system inflammation by therapeutic interventions.