DiseaseComps: a metric that discovers similar diseases based upon common toxicogenomic profiles at CTD.
DiseaseComps: a metric that discovers similar diseases based upon common toxicogenomic profiles at CTD.
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DOI：
10.6026/97320630007154
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发表时间：
2011
期刊：
影响因子：
1.9
通讯作者：
Mattingly CJ
中科院分区：
文献类型：
--
作者：
Davis AP;Rosenstein MC;Wiegers TC;Mattingly CJ
比较毒物基因组学数据库（CTD）是一个描述化学-基因-疾病网络的免费资源，有助于了解环境暴露对人类健康的影响。该数据库包含超过13,500种化学疾病和14,200种基因疾病相互作用。在CTD中，化学物质和基因通过两种类型的关系与疾病相关：作为疾病的生物标志物或分子机制（m型），或作为疾病的实际或假定的治疗方法（t型）。我们利用这些精心整理的数据集来计算相似性指数，这些指数可用于基于共享的毒物基因组图谱生成可比较疾病列表（“疾病列表”）。这种新的指标现在用共同的分子特征对疾病进行分类，而不是使用组织学或起源组织来定义疾病的传统方法。在“个性化医疗”的黎明时代，这一特征提供了一种观察和描述疾病的新方法，并将有助于发展关于化学-基因-疾病网络的可测试假设。该数据库可在http://ctd.mdibl.org/上免费获得
The Comparative Toxicogenomics Database (CTD) is a free resource that describes chemical-gene-disease networks to help understand the effects of environmental exposures on human health. The database contains more than 13,500 chemical-disease and 14,200 gene-disease interactions. In CTD, chemicals and genes are associated with a disease via two types of relationships: as a biomarker or molecular mechanism for the disease (M-type) or as a real or putative therapy for the disease (T-type). We leveraged these curated datasets to compute similarity indices that can be used to produce lists of comparable diseases (“DiseaseComps”) based upon shared toxicogenomic profiles. This new metric now classifies diseases with common molecular characteristics, instead of the traditional approach of using histology or tissue of origin to define the disorder. In the dawning era of “personalized medicine”, this feature provides a new way to view and describe diseases and will help develop testable hypotheses about chemical-gene-disease networks. The database is available for free at http://ctd.mdibl.org/