Learned material content and acquisition level modulate cerebral reactivation during posttraining rapid-eye-movements sleep
Learned material content and acquisition level modulate cerebral reactivation during posttraining rapid-eye-movements sleep
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DOI：
10.1016/s1053-8119(03)00278-7
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发表时间：
2003-09-01
期刊：
影响因子：
5.7
通讯作者：
Maquet, P
中科院分区：
文献类型：
--
作者：
Peigneux, P;Laureys, S;Maquet, P
我们之前已经证明，在清醒时的序列学习和随后的快速眼动（REM）睡眠期间，大脑的几个区域都被激活了（Nat. Neurosci. 3(2000) 831-836），这表明快速眼动睡眠参与了人类近期记忆痕迹的再加工。然而，再处理信息的性质仍然是开放的。本研究表明，在训练后的快速眼动睡眠期间，大脑区域再激活不仅与在先前的连续反应时间任务练习中获得基本的视觉运动技能有关，而且与定义刺激序列的概率规则的内隐获得有关。此外，重新激活的楔叶和纹状体之间的功能连接——后者对内隐序列学习至关重要——在进行概率而非随机刺激序列练习后的快速眼动睡眠中得到加强。因此，我们的研究结果支持了快速眼动睡眠深度参与学习材料中高阶信息的再加工和优化的假设。此外，我们表明，在睡眠前获得概率规则的水平与随后的快速眼动睡眠期间区域脑血流量的增加有关。这表明，训练后的大脑再激活是由学习过程中形成的记忆痕迹的强度调节的。我们的数据为快速眼动睡眠期间的行为表现和大脑再激活之间的联系提供了第一个实验证据。(C) 2003 Elsevier Inc.版权所有。
We have previously shown that several brain areas are activated both during sequence learning at wake and during subsequent rapid-eye-movements (REM) sleep (Nat. Neurosci. 3 (2000) 831-836), suggesting that REM sleep participates in the reprocessing of recent memory traces in humans. However, the nature of the reprocessed information remains open. Here, we show that regional cerebral reactivation during posttraining REM sleep is not merely related to the acquisition of basic visuomotor skills during prior practice of the serial reaction time task, but rather to the implicit acquisition of the probabilistic rules that defined stimulus sequences. Moreover, functional connections between the reactivated cuneus and the striatum-the latter being critical for implicit sequence learning-are reinforced during REM sleep after practice on a probabilistic rather than on a random sequence of stimuli. Our results therefore support the hypothesis that REM sleep is deeply involved in the reprocessing and optimization of the high-order information contained in the material to be learned. In addition, we show that the level of acquisition of probabilistic rules attained prior to sleep is correlated to the increase in regional cerebral blood flow during subsequent REM sleep. This suggests that posttraining cerebral reactivation is modulated by the strength of the memory traces developed during the learning episode. Our data provide the first experimental evidence for a link between behavioral performance and cerebral reactivation during REM sleep. (C) 2003 Elsevier Inc. All rights reserved.