The importance of water exchange rates in the design of responsive agents for MRI.
The importance of water exchange rates in the design of responsive agents for MRI.
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DOI：
10.1016/j.cbpa.2012.12.012
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发表时间：
2013-04
影响因子：
7.8
通讯作者：
Wu, Yunkou
中科院分区：
文献类型：
--
作者：
Sherry, A. Dean;Wu, Yunkou
镧系元素配合物中的水交换速率作为响应性MR成像剂的设计中的重要参数常常被忽视。通常，内球水配位位点的数量或复合体的旋转流动性被认为是中心主题，而水交换要么被假设为“足够快”，要么被完全忽略。另一方面，弛豫和位移理论预测，水交换速率可能确实是任何新分子设计中应该考虑的关键参数。在这篇简短的评论中，水交换率对三类镧系元素为基础的MRI造影剂，T1为基础的弛豫剂，T2交换线增宽剂和化学交换饱和转移（CEST）剂的影响，进行了说明和讨论。
The rate of water exchange in lanthanide complexes is often overlooked as an important parameter in the design of responsive MR imaging agents. Most often, the number of inner-sphere water coordination sites or the rotational mobility of the complex are considered as the central theme while water exchange is either assumed to be “fast enough” or entirely ignored. On the other hand, relaxation and shift theories predict that water exchange rates may indeed be the key parameter one should consider in any new molecular design. In this short review, the impact of water exchange rates on three classes of lanthanide-based MRI contrast agents, T1-based relaxation agents, T2 exchange line-broadening agents and chemical exchange saturation transfer (CEST) agents, is illustrated and discussed.
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影响因子：
2.9
作者：
Soesbe, Todd C.;Wu, Yunkou;Dean Sherry, A.
通讯作者：
Dean Sherry, A.
影响因子：
4.9
作者：
Caravan, Peter;Das, Biplab;Zhang, Zhaoda
通讯作者：
Zhang, Zhaoda
影响因子：
3.3
作者：
GERALDES, CFGC;SHERRY, AD;SPILLER, M
通讯作者：
SPILLER, M
DOI：
10.1073/pnas.1109649108
发表时间：
2011-11-08
影响因子：
11.1
作者：
Lubag, Angelo J. M.;De Leon-Rodriguez, Luis M.;Sherry, A. Dean
通讯作者：
Sherry, A. Dean
影响因子：
16.6
作者：
Moats, RA;Fraser, SE;Meade, TJ
通讯作者：
Meade, TJ