Simplified Assessment of Segmental Colonic Transit
Simplified Assessment of Segmental Colonic Transit
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DOI：
10.1016/0016-5085(87)90837-7
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发表时间：
1987-01-01
期刊：
影响因子：
29.4
通讯作者：
Wolff, Bruce G.
中科院分区：
文献类型：
--
作者：
Metcalf, Amanda M.;Phillips, Sidney F.;Wolff, Bruce G.
通过已发表的技术测量不透射线标记物通过人体肠道的通过时间，并与简化方法进行比较。24名健康人连续3天摄入3组特异性标志物。在研究的第一部分，每天进行腹部X线检查，并收集个体粪便进行X线摄影。根据标记物的粪便排出量评估口肛门转运，并根据每日X线片计算平均结肠和节段结肠转运。然后将这些建立的方法与基于第四天拍摄的单一腹部胶片的总结肠和节段转运的估计值进行比较。单膜技术相关性以及从以前的，但更不方便，方法获得的值。使用更简单的方法，在另外49名健康受试者中评估结肠运输，总共73人。总结肠转运时间为35.0 ± 2.1 h（平均值± SE）;右半结肠段性转运时间为11.3 ± 1.1 h，左结肠段性转运时间为11.4 ± 1.4 h，直肠乙状结肠段性转运时间为12.4 ± 1.1 h。男性的整个结肠转运时间明显短于女性（p < 0.05），这种差异在某种程度上在右半结肠（p = 0.06）和左半结肠（p = 0.07）中明显，但在直肠乙状结肠中不明显。年龄并没有影响运输显着，也没有一个小剂量的补充纤维。该技术简单，便于临床使用，并将辐射暴露降低到可接受的水平。这种方法在评价选定患者的结肠传输中应该有一定的作用。
Transit times of radiopaque markers through the human gut were measured by published techniques and compared with a simplified method. Three sets of distinctive markers were ingested by 24 healthy persons on 3 successive days. In the first part of the study, daily abdominal x-rays were taken and individual stools were collected for radiography. Mouth-to-anus transits were assessed from the fecal output of markers and mean colonic and segmental colonic transits were calculated from the daily radiographs. These established methods were then compared with estimates of total colonic and segmental transits based on a single abdominal film, taken on the fourth day. The single-film technique correlated well with values obtained from the previous, but more inconvenient, methods. Using the simpler approach, colonic transit was assessed in 49 additional healthy subjects, for a total group of 73. Total colonic transit was 35.0 +/- 2.1 h (mean +/- SE); segmental transits were 11.3 +/- 1.1 h for the right colon, 11.4 +/- 1.4 h for the left colon, and 12.4 +/- 1.1 h for the rectosigmoid. Men had significantly shorter transits for the whole colon than did women (p < 0.05), and this difference was apparent to some extent in the right (p = 0.06) and left colon (p = 0.07) but not in the rectosigmoid. Age did not influence transit significantly nor did a small dose of supplemental fiber. The technique is simple, convenient for clinical usage, and reduces the exposure to radiation to acceptable levels. There should be a role for this approach in the evaluation of colonic transit in selected patients.