Fucoidans from Brown Seaweeds Sargassum hornery, Eclonia cava, Costaria costata: Structural Characteristics and Anticancer Activity
Fucoidans from Brown Seaweeds Sargassum hornery, Eclonia cava, Costaria costata: Structural Characteristics and Anticancer Activity
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DOI：
10.1007/s12010-011-9178-2
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发表时间：
2011-07-01
影响因子：
3
通讯作者：
Zvyagintseva, Tatyana
中科院分区：
文献类型：
--
作者：
Ermakova, Svetlana;Sokolova, Roza;Zvyagintseva, Tatyana
通过水提取和离子交换色谱法从韩国沿海采集的褐藻Eclonia cava、Sargassum hornery和Costaria costata中分离岩藻聚糖。对岩藻聚糖的结构进行了研究。褐藻糖胶E. Cava是硫酸化的鼠李半乳岩藻聚糖和半乳岩藻聚糖的混合物。褐藻糖胶C. costata是硫酸化的半乳藻聚糖。从S.将角质物分离成三种级分：硫酸高岩藻聚糖、不含硫酸酯基团的高岩藻聚糖和硫酸化的鼠李岩藻聚糖。结果清楚地表明，岩藻多糖在人黑色素瘤和结肠癌细胞的集落形成中起抑制作用，并且可能是有效的抗肿瘤剂。
Fucoidans were isolated by water extraction and ion-exchange chromatography from brown algae Eclonia cava, Sargassum hornery, and Costaria costata collected near of Korean coasts. The structures of fucoidans were investigated. Fucoidan from E. cava was mixture of sulfated rhamnogalactofucan and galactofucan. Fucoidan from C. costata was a sulfated galactofucan. Fucoidan isolated from S. hornery was separated into three fractions: a homofucan sulfate, a homofucan but without sulfate groups, and a sulfated rhamnofucan. The results clearly showed that fucoidans play an inhibitory role in colony formation in human melanoma and colon cancer cells and may be effective antitumor agents.