FACILITATION OF HUMAN TOBACCO SELF-ADMINISTRATION BY ETHANOL - BEHAVIORAL-ANALYSIS
FACILITATION OF HUMAN TOBACCO SELF-ADMINISTRATION BY ETHANOL - BEHAVIORAL-ANALYSIS
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DOI：
10.1901/jeab.1976.25-279
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发表时间：
1976-01-01
影响因子：
2.7
通讯作者：
LIEBSON, I
中科院分区：
文献类型：
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作者：
GRIFFITHS, RR;BIGELOW, GE;LIEBSON, I
在住宅实验室中，研究了酒精对酒精依赖者吸烟的影响。在每天6小时的疗程中，通过向病房工作人员提出要求或通过操作杠杆(固定比例为5或10)获得香烟。在几天的混合序列中，疗程包括单独摄入赋形剂(橙汁)或赋形剂加乙醇(133.7克)。在饮酒期间，吸烟率从车辆水平的26%-117%上升。一系列对照研究消除了导致观察到的效果的一些潜在的行为机制，并表明酒精导致的吸烟增加发生在各种实验条件下：当吸烟不能与酒精或车辆消费同时发生时；当受试者不被允许社交时；当连续几天摄入乙醇或车辆时；以及在盲目条件下服用不同剂量的乙醇时。在对照实验中，称重未吸烟的烟草并计算每支烟的吸烟量表明，这种影响并不是因为每支烟抽得更少。这种影响并不局限于实验阶段，因为酒精日的总吸烟量比开车日要高。
The effect of ethanol on the cigarette smoking of alcholic subjects was studied in a residential laboratory. During daily 6-h sessions, cigarettes were obtained either by request to the ward staff or by operation of a lever (fixed-ratio 5 or 10). In a mixed sequence across days, sessions involved ingestion of either vehicle (orange juice) alone or vehicle plus ethanol (133.7 g). During ethanol sessions the rate of cigarette smoking increased from 26-117% of vehicle levels. A series of control studies eliminated a number of potential behavioral mechanisms for the observed effect and indicated that the ethanol-induced increase in cigarette smoking occurred under a variety of experimental conditions: when smoking could not occur concurrently with ethanol or vehicle consumption; when subjects were not allowed to socialize; when ingestion of ethanol or vehicle was scheduled for a number of consecutive days; and when various doses of ethanol were administered under blind conditions. In control experiments weighing unsmoked tobacco and counting the number of puffs/cigarette indicated the effect was not due to smoking less of each cigarette. The effect was not limited to the experimental sessions alone, since total daily smoking was higher on ethanol days than vehicle days.