Permanent reduction in heart and kidney organ growth in offspring of undernourished rat dams
Permanent reduction in heart and kidney organ growth in offspring of undernourished rat dams
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DOI：
10.1016/j.ajog.2005.05.041
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发表时间：
2005-09-01
影响因子：
9.8
通讯作者：
Ross, MG
中科院分区：
文献类型：
--
作者：
Desai, M;Gayle, D;Ross, MG
目的：母体营养不良影响胎儿生长发育。我们调查了母亲在怀孕和/或哺乳期的食物限制是否永久改变成年后代的器官growth among adults.Study design：从10天到足月妊娠，并通过21天的哺乳期，对照妊娠大鼠接受自由采食食物，而研究大鼠50%的食物限制。交叉寄养技术被用来检查在怀孕和/或哺乳期的食物限制的影响。器官进行解剖和称重（体重的百分比）在3周和9 months.Results：在怀孕期间的食物限制产生的生长受限的新生儿，表现出追赶增长，导致显着较重的成年后代，虽然与心脏，肾脏，肺，和大脑的重量相对下降，与对照组相比。相反，在怀孕/哺乳期或哺乳期单独限食导致成年后代的体重与对照组相似，但心脏和肾脏的生长相对下降。男性表现出相对较小的肝脏，而女性表现出相对较小的肾上腺。结论：性别依赖性，选择性和永久性的变化，在相对增长的心脏和肾脏可能会增加成年疾病的风险。(C)2005 Mosby，Inc. All rights reserved.
Objective: Maternal undernutrition affects fetal growth and development. We investigated whether maternal food restriction during pregnancy and/or lactation permanently alters organ growth among adult offspring.Study design: From 10 days to term gestation and through 21 days lactation, control pregnant rats received ad libitum food, whereas study rats were 50% food restricted. Cross-fostering techniques were used to examine the effects of food restriction during pregnancy and/or lactation periods. Organs were dissected and weighed (percentage of body weight) at ages 3 weeks and 9 months.Results: Food restriction during pregnancy produced growth- restricted newborns that exhibited catch-up growth that resulted in markedly heavier adult offspring, although with relatively decreased weights of heart, kidney, lung, and brain as compared with controls. Conversely, food restriction during pregnancy/lactation or lactation alone resulted in adult offspring with similar body weights as controls, but with relatively decreased growth of heart and kidney. Males exhibited relatively smaller livers, whereas the females showed relatively smaller adrenal glands.Conclusion: Sex-dependent, selective, and permanent changes in relative growth of heart and kidney may increase risk of adult diseases. (C) 2005 Mosby, Inc. All rights reserved.